31例慢性粒细胞性白血病患者染色体追踪观察  

Observation of karyotypic changes in 31 cases of chronic myeloid leukemia

作　　者：戴盛明[1] 李湧[1] 谭鹤长[1] 黄培山[1] 韦叶育[1] 王慧芳[1] 黄崇媚[1] 邵晶旋[1] 

机构地区：[1]广西柳州市工人医院 广西医科大学第四附属医院,柳州545005

出　　处：《医学文选》2006年第3期371-373,共3页Anthology of Medicine

摘　　要：目的探讨慢性粒细胞性白血病（CML）的染色体核型在病程中的变化与临床关系。方法采用24h、48h培养法制备骨髓染色体，G显带技术对31例Ph＋CML患者进行染色体核型追踪分析。结果有10例发生了新的额外染色体异常改变，占32．2%。额外染色体异常有＋12，＋15，＋21，18q＋，i（17q），r（2），r（17）等，以及两条染色体间的易位，这些出现二次染色体畸变病例多在检出新的额外染色体异常后半年左右因化疗不敏感或急变死亡。结论Ph＋CML患者在病程中出现额外染色体畸变，提示临床疗效差，预后不良。通过细胞遗传学染色体核型追踪分析有助于对CML临床疗效观察以及预后判断。Objective To investigate the relationship between karyotypic changes of chronic myeloid leukemia （CML） and clinical prognosis. Methods Chromosome preparations were made from bone marrow cells by 24h or 48h culture, and the karyotypic changes of 31 Ph ＋ CML cases were traced by G-banding technique. Results 10 of 31 cases （32.2%） were new additional chromosomal abnormalities, including ＋ 12, ＋ 15, ＋ 21, 18q ＋, i（17q）, r（2）, r（17） and translocation of two chromosomes, and died of nonsensitivity to chemotherapy or blastic phase within 6 months after detection of new additional chromosomal abnormality. Conclusion Ph ＋ CML with additional chromosomal abnormality is of poor curative effect and prognosis. Cytogenetic chromosomal analysis of CML is helpful for it＇s curative effect and prognosis.

关 键 词：白血病 染色体 细胞遗传学 

分 类 号：R733.72[医药卫生—肿瘤]