苯丁酸钠联合其他诱导分化剂治疗难治性白血病2例疗效观察  

Application of phenylbutyrate to differentiation therapy of hematological malignancies

作　　者：古国亚[1] 陈钰[2] 刘元 陈瑜[2] 曾晓颖[2] 童建华[2] 胡炯[2] 陈赛娟[2] 沈志祥[2] 

机构地区：[1]安徽省铜陵市人民医院血液科,安徽铜陵244000 [2]上海第二医科大学附属瑞金医院血液科

出　　处：《安徽医药》2006年第7期494-495,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨苯丁酸钠在血液肿瘤诱导分化治疗中的应用方法。方法以苯丁酸钠为基础,同时加用ATRA、G-CSF、地塞米松。结果2例患者在治疗15 d后均取得了血液学改善,并取得了骨髓缓解。结论苯丁酸钠和其它诱导分化剂联合应用可能是部分血液肿瘤有效的诱导分化治疗方法。Aim To determine the application of phenylbutyrate to differentiation therapy of hematological malignancies. Methods Sodium phenylbutyrate was used as a primary medicine, combined with ATRA, G-CSF and dexamethasone. Results Both of the 2 cases achieved hematological improvement in 15 days after treatment, and obtained bone marrow remission finally. Conclusion Phenylbutyrate combined with other differentiation agents may be an effective differentiation therapy in a proportion of hematological malignancies.

关 键 词：苯丁酸钠 诱导分化治疗 诱导分化剂 

分 类 号：R733.7[医药卫生—肿瘤]