抽动障碍患儿事件相关电位P_(300)的研究  

Detection of P_(300) in children with tic disorders

作　　者：胡莲清[1] 郑璇[1] 欧利民[1] 林丽丽[1] 庄伟端[1] 吴育彬[1] 郑俊忠[1] 肖颖秀[1] 

机构地区：[1]汕头大学医学院附属一医院儿科,汕头515041

出　　处：《中国行为医学科学》2006年第7期612-613,共2页Chinese Journal of Behavioral Medical Science

基　　金：2003年广东省医学科学技术研究基金项目(2003A500)

摘　　要：目的了解抽动障碍患者事件相关电位P300的变化及意义。方法用日本光电公司提供的MEB-9104K诱发电位检测系统测定41例抽动障碍患者(病例组)P300并与22例正常儿童(对照组)进行比较。结果病例组P300潜伏期为(582.7±137.4)m s,波幅为(24.78±10.25)μV,对照组潜伏期为(501.2±126.0)m s,波幅为(23.15±10.00)μV。2组潜伏期均值比较,差异有显著性(P<0.01);波幅均值比较,差异无显著性(P>0.05)。病例组各亚型之间P300潜伏期及波幅比较,均差异无显著性(P>0.05)。病例组中治疗组与未治疗组之间P300潜伏期及波幅比较,均差异无显著性(P>0.05)。结论抽动障碍患者存在认知功能缺陷,在治疗该类患者的过程中值得参考。抽动障碍各亚型之间认知功能无明显差别。氟哌啶醇、泰必利等药物治疗抽动障碍对认知功能无影响。Objective To study the change of event-related potentials （ERPs） P300 and its significances in children with tic disorders （TD）. Methods P300 of 41 children with TD （case group） and 22 healthy children （control group） were taken. The results of case group and control group were compared with each other. Results Pwo latency was significantly longer in the case group than that in the control subjects（ P 〈 0.05 ） while there was no obvious difference between amplitude. There were no significant differences of latency and amplitude between subgroups of the patients. It was the same as that of the treated group vs untreated group. Conclusion Children with TD showed impaired cognition. It was significant to take ERP-P300 while treating with patients with TD to evaluate their cognitive function . Haloperidal and Tiapiride did not affect the cognition of the patients.

关 键 词：抽动性运动障碍 事件相关电位 认知 

分 类 号：R749.94[医药卫生—神经病学与精神病学]