非靶受体在精神活性物质依赖中的作用  

ROLE OF NON-TARGET RECEPTORS IN PSYCHOACTIVE SUBSTANCE DEPENDENCE

作　　者：房蕾[1] 朱永平[1] 

机构地区：[1]浙江大学医学院毒理研究室,杭州310006

出　　处：《中国药物依赖性杂志》2006年第3期181-186,共6页Chinese Journal of Drug Dependence

基　　金：国家重点基础研究发展计划(973计划)"精神活性物质依赖的生物学基础及防治"(2003CB515400)资助项目;浙江省科技计划重点项目(2005C23G2010166)资助

摘　　要：当前精神活性物质滥用和成瘾呈上升趋势,它既是一个严重的社会问题,又是一个非常重要的生物学问题。在我国导致精神依赖的活性物质主要是阿片类。精神活性物质作用的靶受体为阿片受体,非靶受体主要包括多巴胺受体、N-甲基-D-门冬氨酸(NMDA)受体和组胺等。本文主要论述NMDA受体和组胺受体等非靶受体在精神活性物质依赖发生发展过程中功能和结构上的变化,探讨精神活性药物成瘾的机制,研究和开发以NMDA和组胺受体为靶标的新药,为阿片类药物成瘾的防治开辟新的研究领域。At present, psychoactive substance abuse and addiction become more severe. It is not only a serious social issue, but also an important biological problem. One of the most abused substances in our country is opioid. The target receptor of psychoactive substance is opioid receptor and the non - target receptor mainly includes dopamine receptor, NMDA receptor, histamine receptor, and so on. This article mainly summarizes the functional and structural changes of these non - target receptors in the developing process of dependence on psychoactive substance, and discusses the mechanism of addiction. Furthermore, the research and development of new drugs that act on NMDA or histamine receptors as the target will open a new field of preventing and controlling opioid addiction.

关 键 词：NMDA受体 组胺 非靶受体 精神活性物质 依赖 

分 类 号：R749.6[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]