多西他赛同步放疗治疗老年晚期非小细胞肺癌  

Concurrent taxotere and radiotherapy for elderly patients with advanced non-small cell lung cancer

作　　者：刘海燕[1] 张艳英[1] 宋延梅[1] 

机构地区：[1]泰山医学院附属医院肿瘤科,山东泰安271000

出　　处：《实用医药杂志》2006年第7期786-788,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的观察多西他赛同步放疗治疗老年晚期非小细胞肺癌(NSCLC)的疗效及毒副反应。方法对病理学或细胞学证实的32例老年晚期非小细胞肺癌患者给予下列治疗:①多西他赛35mg/m2,静脉滴注,于放疗前1d开始,1次/周,共4次;②给予6-mVX-线常规体外照射,1.8～2Gy/次,5次/周,总量50～60Gy/5～6周。结果初治患者有效率86.4%,复治患者有效率40%,总有效率68.8%,中位生存期10个月。不良反应:食管炎56.4%,白细胞减少46.4%,放射性肺炎17.6%。无治疗相关的病死。结论多西他赛同步放疗治疗老年晚期NSCLC疗效满意,耐受性好。Objective To evaluate the therapeutic significance of concurrent taxotere and radiotherapy for elderly patients with advanced non-small cell lung cancer （NSCLC）.Methods Elderly patients with advanced NSCLC received 6-MV X rays at split-course schedule with the total dose of 50-60Gy/5-6 weeks and taxotere,35mg/m^2,administered on the first day of each radiotherapy week.Results Of 32 patients enrolled,the objective response occurred in 86.4% of chemo-navepatients and 40% of the others,the overall response rate was 68.8%.The media duration of survival was 8.5 months.The more frequent toxieities were esophagitis,leueopenia and pneumonitis （56.4%,46.4% and 17.6%,respeetively）.No serious toxicity and treatment related death occurred.Conclusion This regiment was well-tolerated and effective in elderly patients with advanced NSCLC.

关 键 词：多西他赛 放射治疗 老年 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]