nm23、p53、PCNA在结肠癌中的表达及其临床意义  

Expression of nm23,p53 and PCNA in colonic carcinoma and their clinical significance

作　　者：范瑞[1] 秦长岭[1] 

机构地区：[1]河南省南阳市第一人民医院病理科,南阳473010

出　　处：《中原医刊》2006年第14期28-30,共3页Central Plains Medical Journal

摘　　要：目的探讨nm23、p53、PCNA表达与结肠癌临床病理特征和预后的关系。方法运用免疫组织化学法观察46例结肠癌nm23、p53、PCNA表达。结果46例结肠癌中,高分化腺癌、中低分化腺癌的nm23检出率分别为81.8%(9/11)、62.1%(22/35),浆膜外癌细胞阳性率明显低于肌层,有、无淋巴结转移阳性表达率分别为61.1%(11/18)、85.7%(24/28)。p53在结肠癌中阳性表达率为65.2%(30/46),在浆膜外层的阳性表达率为83.3%(5/6),肌层62.5%(25/40)。p53表达与结肠癌的组织类型、分化程度和淋巴结转移未见明显相关,而与浸润深度呈正相关。PCNA该组检出率为100%,只是染色强弱有别,与病理分级、浸润与淋巴结转移未见明显相关性。结论p53和nm23表达与结肠癌的临床生物学行为密切相关,特别是与结肠癌转移和浸润深度关系密切,为结肠癌的临床治疗、手术成功率判断及肿瘤转移和转移的基因治疗提供了线索。Objective To study the relation ship between the expression of nm23,p53 ＆PCNA and clinicopathologic features ＆ prognosis of colonic carcinoma. Methods Immunohistochemical stains were used to investigate the expression of nm23, p53 and PCN＇A in 46 cases of colonic carcinoma. Results Rates of the expression of nm23 in colonic carcinoma of higher and lower - middle differentiation were 81.8% and 62. 1% respectively. 61.1% cases had lymph node metastasis and 85.7% no lymph node metastasis and invading outside serosa was obviously lower than in the colon muscle. The positive rate of p53 was 65.2% ,83.3% outside serosa,62.5% in the muscle, p53 expression showed no relation to the histopathological classification, degree of differentiation or lymph node metastasis,and had positive correlation to aggressiveness. Rate of PCNA was 100% ,whether the degree of staining was associated with grade of histopathology, invasion and lymph node metastasis or not. Conclusion Expression of p53 and nm23 are closely related to especially invasion and metastasis,biological behavior of colonic carcinoma, and may be served as an evidence for treatment, successing rate of operation and genetic treatment of clolonic carcinoma.

关 键 词：NM23 P53 PCNA 结肠癌 

分 类 号：R735.34[医药卫生—肿瘤]