地高辛的体内分析方法应用与进展  

Application and progression of biopharmaceutical analyzing methods of digoxin

作　　者：蒲晓辉[1] 赵辉[1] 李好枝[2] 

机构地区：[1]河南大学药学院,河南开封475001 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2006年第7期471-476,共6页Journal of Shenyang Pharmaceutical University

摘　　要：目的总结地高辛血药质量浓度监测方法,寻求最适的测定方法。方法对近年来国内外与地高辛监测相关的文献进行检索综述分析。结果地高辛血药浓度测定方法很多,常用方法主要有:FPIA、酶免疫分析法、RIA、CLIA、乳胶免疫抑制法、干化学法、HPLC法等。结论通过比较分析其中RIA、CLIA、EIA和HPLC MS 4种方法更好。Objective To summarize monitoring methods of serum digoxin concentrations in order to find the most suitable method. Methods The literatures related to the monitor of serum digoxin concentration were analyzed. Results The main methods included FPIA, EIA, RIA, CLIA, LCIA, DC, HPLC. Conclusions By comparing and analyzing all kinds of methods, RIA, CLIA and HPLC-MS are the best ones.

关 键 词：地高辛 血药浓度测定 免疫分析法 干化学法 高效液相色谱法 

分 类 号：R914.1[医药卫生—药物化学]