急性有机磷中毒患者血清蛋白改变的意义  

Changes of plasma protein in the patients with acute organophosphorus poisoning and its clinical meaning

作　　者：刘海英[1] 展晖[2] 张瑞霞[1] 刘新华[1] 

机构地区：[1]新乡医学院第一附属医院检验科,河南卫辉453100 [2]新乡医学院研究生部

出　　处：《中国急救医学》2006年第7期496-497,共2页Chinese Journal of Critical Care Medicine

基　　金：河南省科技厅科技攻关项目(No.0324410078)

摘　　要：目的探讨急性有机磷中毒(AOPP)患者血清蛋白改变的临床意义。方法根据患者入院时中毒程度的不同分为轻、中、重度中毒三组,在患者入院3 d内采集静脉血3 mL做血清总蛋白(TP)、白蛋白(ALB)、球蛋白(GLO)、白球比(A/G)和C-反应蛋白(CRP)等项目的检测,并选30例健康查体者作对照(排除一切与蛋白质浓度改变有关的疾病),门诊采血一次,检测项目与方法同疾病组。结果疾病组与健康对照组比较,除轻度中毒组TP、GLO和中度中毒组GLO浓度改变无统计学意义外,其余各项改变均有统计学意义(均P<0.01)。蛋白质浓度改变与中毒程度有关,不同程度中毒组间检测结果的异常程度比较,各项均呈重度中毒组>中度中毒组>轻度中毒组。结论观察蛋白浓度的改变对判断中毒程度、了解机体的损害状况、指导临床治疗有重要帮助。Objective To study the clinical significance and changes of plasma protein in the patients with acute organophosphoms poisoning（AOPP）. Methods Patients were divided into three groups according to the degree of poisoning ：the mild,mederate and severe groups. 3 mL bloods samples were collected to measere total pmtrin （TP）, allbumin（ ALB ）, globulin （ GID ）, allbumin/globulin （ A/G ） and c - reactive protein（CRP） on the 3th day for each group,meanwhile, 30 healthy volunteers were measured as control（ to eliminate all diseases that can change protein）. Control group was measured for one time. Results Diseased group was compared with control group, except for the GID,all others are obvilus different（ P〈0.01） .Different degree poisoning groups compared with control group,except that TP, GLO in the mile and GI.D in the mederate were not different,all others were obvious different（ P 〈 0.01）. The change of protein relates to the degree of poisoning. Compared the different poisoning group the results were severe group 〉moderate〉mild. Conclusion To study the change of protein was helpful to monitor the degree of poisoning and guide treatment for patients with acute organophosphorus poisoning.

关 键 词：蛋白质 有机磷中毒 营养 治疗 

分 类 号：R595.4[医药卫生—内科学] R446.11[医药卫生—临床医学]