脑梗死患者血浆神经降压素动态变化及其临床意义  

Changes of plasma neurotensin level and their clinical significance in patients with cerebral infarction

作　　者：于叔麒[1] 张巧俊[1] 高敬龙[2] 郑纯礼[1] 袁海峰[1] 万婷玉[1] 

机构地区：[1]西安交通大学第二医院神经内科,陕西省人民医院710004 [2]陕西省人民医院

出　　处：《中国康复医学杂志》2006年第6期514-516,共3页Chinese Journal of Rehabilitation Medicine

基　　金：陕西省自然科学基金资助项目(2002C269)

摘　　要：目的:观察脑梗死患者血浆神经降压素(NT)的水平变化并探讨其临床意义。方法:脑梗死患者74例,其中合并糖尿病者46例,合并高血压者45例;临床神经功能缺损评分轻度23例,中度33例,重度18例;梗死面积大灶19例,小灶55例;积分<6分17例,≥6分57例;正常对照66例。用放射免疫实验技术(法)测定血浆中的NT含量并观察其动态变化情况。结果:脑梗死患者的血浆NT水平较正常对照组显著性升高(P<0.0001),发病后24h内明显升高,7天内达高峰,8—15天开始下降,15天后仍在较高水平;临床神经功能缺损评分重度血浆NT水平较中度显著性升高(P<0.0001),中度较轻度显著性升高(P<0.0001);大灶组较小灶组显著性升高(P<0.01)。结论:脑梗死患者NT变化以7天内最显著,15天后逐渐恢复正常;NT浓度检测可作为病情严重程度、病灶大小的实验室指标。Objective：To study changes of plasma neurotensin level and their clinical significance in patients with cerebral infarction.Method：Seventy-four patients with cerebral infarction were enrolled in this study. Of these 74 patients 46 patients had diabetes,45 had hypertension.Sixty-six healthy individuals were served as controls.Neurotensin level were measured by radioimmunoassay.Result： In the test group, levels of NT increased more than in the control group （P〈0.0001）. They started to increase significantly during the first day, and began to decrease on the 7tb day later. There was a significant correlation between those indicators and some complicated diseases of cerebral infarction.Conclusion：The level changes of NT with cerebral infarction were most significant on the 7th days, and gradually recovered to normal levels within 15 days. NT may be used as laboratory markers for ranking the severity of patient＇s condition and bulk of cerebral infarction.

关 键 词：脑梗死 神经降压素 神经功能缺损评分 放射免疫实验技术 

分 类 号：R743.33[医药卫生—神经病学与精神病学]