趋化因子受体CCR7在乳腺癌淋巴结转移中的作用  

Effect of chemokine receptor CCR7 in breast cancer tissue on lymph node metastasis

作　　者：朱旬[1] 甄林林[1] 郑伟[1] 王汉晋[1] 王萱仪[1] 武正炎[1] 

机构地区：[1]南京医科大学第一附属医院普外科,江苏南京210029

出　　处：《第四军医大学学报》2006年第13期1205-1207,共3页Journal of the Fourth Military Medical University

摘　　要：目的:探讨趋化因子受体CCR7在乳腺癌中的表达意义.方法:应用RT-PCR及免疫组织化学方法检测42例乳腺癌组织和10例乳腺纤维腺瘤中CCR7的表达.结果:在乳腺癌组织中CCR7 mRNA表达42.9%,CCR7蛋白表达35.7%,在乳腺纤维腺瘤中仅有1例CCR7 mRNA表达.无淋巴结转移者CCR7蛋白阳性表达率为11.1%(2/18),而有淋巴结转移阳性表达率为54.2%(13/24)(P<0.01);临床TNM分期Ⅰ,Ⅱ,Ⅲ期的阳性表达率分别为0%,39.1%,60.0%(P<0.01).结论:CCR7可能是介导淋巴结转移和组织浸润的重要机制之一.AIM： To detect the expressions of chemokine receptor CCR7 protein and its mRNA in breast carcinoma, and to discuss their relationship with lymph node metastasis. METHODS： The expressions of chemokine receptor CCR7 mRNA and protein in 42 cases of breast carcinoma and 10 cases of breast fibroadenoma tissue were detected by reverse transcriptionpolymerase chain reaction （RT-PCR） and SP immunohistochemical technique, RESULTS： There were 18 cases of positive expression of CCR7 mRNA and 15 of CCR7 protein in 42 cases of breast carcinoma tissue. The positive expression rate of CCR7 protein （ 11, 1% ） in patients without lyphm node metastasis was significantly lower than that （54.2%） in patients with lyphm node metastasis （P 〈 0, 01 ）, The positive rate in clinical stage Ⅰ , Ⅱ and Ⅲ were 0%, 39, 1%, 60.0%, respectively （P 〈 0, 01 ）, The positive expression of CCR7 was correlated with lymph node metastasis as well as clinical stage. CONCLUSION： CCR7 may contribute to lyphm node metastasis in breast cancer.

关 键 词：乳腺肿瘤 转移 淋巴结 CCR7 

分 类 号：R730.7[医药卫生—肿瘤]