膀胱低度恶性潜能乳头状尿路上皮肿瘤12例临床病理分析  

Report of 12 Cases of Papillary Urothelial Neoplasm of Low Malignant Potential of the Urinary Bladder with Clinicopathological Analysis and Review of the Literature

作　　者：曹雅静[1] 范嫏娣[1] 冯起庆[1] 关剑[1] 张丽[1] 

机构地区：[1]天津人民医院病理科,天津市300121

出　　处：《中国肿瘤临床》2006年第13期771-773,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:结合文献复习探讨膀胱低度恶性潜能乳头状尿路上皮肿瘤(PUNLMP)临床病理学、免疫组化、鉴别诊断及预后。方法:对12例进行经尿道膀胱电切术(TURBt),经病理制片,光镜观察及免疫组化CK20、Ki-67、34!E12标记。结果:12例患者平均年龄为53.3岁,临床症状以血尿为主,膀胱镜检查病损均为<3cm。光镜观察均符合PUNLMP的诊断标准。预后10例获随访12～36月不等,均无复发。结论:膀胱PUNLMP属介于良、恶性之间肿瘤的独立类型,需长期随访,偶有复发,大多数病例不进展为癌,应与低级别癌区分。Objective： To explore the clinicopathological and immunohistochemical features, differential diagnosis, and prognosis of papillary urothelial neoplasm of low malignant potential （PUNLMP）, and to review the literature. Methods： Transurethral resection of bladder tumor （TURBT） was performed on all 12 cases of PUNLMP, and pathological sections were made. Microscopic and immunohistochemical evaluations were performed. Results： The average age of the 12 patients was 53.3 years. Hematuria was the chief symptom. The diameters of all lesions were less than 3 cm based on findings with a cystoscope. The features on microscopy were all consistent with the diagnostic criteria of PUNLMP. Follow-ups were obtained for 10 patients, and the durations ranged from 12 to 36 months. No recurrence was found. Conclusion： PUNLMP in the urinary bladder is a distinct type of intermediate tumor with behavior somewhere between benign and malignant tumors that needs a long period of follow-up. Recurrence is rare. Most cases do not progress into carcinoma. PUNLMP should be differentiated from the low grade carcinomas as a separate entity.

关 键 词：膀胱 低度恶性潜能 尿路上皮肿瘤 

分 类 号：R737.14[医药卫生—肿瘤]