胃癌周围淋巴结微量元素变化的研究  

Changes of trace elements in regional lymph nodes of gastric carcinoma

作　　者：张敬成[1] 李光昭[2] 黄芸生[2] 沈文英[3] 齐朝阳[2] 陈春来[2] 李星洪[2] 

机构地区：[1]汕头大学医学院第一附属医院普通外科,515041 [2]汕头市第二人民医院 [3]汕头大学医学院中心实验室

出　　处：《中华胃肠外科杂志》2006年第4期342-344,共3页Chinese Journal of Gastrointestinal Surgery

基　　金：广东省汕头市科教兴医工程重点科研项目(10-1)

摘　　要：目的研究胃癌组织和癌旁淋巴结微量元素的变化及与胃癌淋巴结转移的关系。方法对40例胃癌患者的胃癌组织、癌转移及元癌转移淋巴结组织进行铁(Fe)、镁(Mg)、锰(Mn)、钙(Ca)、铜(Cu)、锌(Zu)、硒(Se)7种微量元素的测定并进行分析比较。结果胃癌组织、癌转移与无癌转移淋巴结组织中Fe、Mg、Mn、Ca含量比较,差异元统计学意义(P=0．372～0．741,均P＞0．05)；胃癌组织与癌转移淋巴结的7种微量元素相比,差异无统计学意义(P=0．15～0．59,均P＞0．05)；癌转移淋巴结与无癌转移淋巴结的微量元素比较,Zn、Se明显下降,Cu及Cu/Zn上升,差异有统计学意义(P=0．001～0．009,均P＜0．01)；癌转移淋巴结中N_2站的Zn含量低于N_1站Zn,差异有统计学意义(P=0．027)；肠型胃癌中癌转移淋巴结7种微量元素与弥漫型胃癌中癌转移淋巴结比较,差异均无统计学意义(P=0．149～0．758,均P＞0．05)。结论胃癌淋巴结转移过程中伴有体内微量元素的变化；Zn、Cu、Se含量的变化可能与胃癌淋巴结转移机制有关。Objective To explore the relationship between the changes of trace elements and lymphatic metastasis in gastric carcinoma. Methods Trace elements including Fe,Mg,Mn,Ca,Cu,Zn,Se were measured in primary gastric carcinoma and regional lymph nodes from 40 patients with gastric carcinoma, and compared among the primary tumor, metastatic, and non-metastatic nodes. Results There were no significant differences in the contents of Fe, Mg, Mn and Ca among primary gastric tumors, regional lymph nodes with or without metastasis（ P =0. 372 - 0. 741, P 〉 0.05）, and no significant differences in the contents of all 7 trace dements between primary tumors and metastatic lymph nodes（ P = 0. 15-0. 59, P 〉 0.05）. Compared with metastatic lymph nodes, the contents of Zn,Se significantly decreased, while Cu and Cu/Zn significantly increased（ P = 0. 001-0. 009, P 〈 0. 01 ） in non-metastatic lymph nodes. The content of Zn in N2 positive lymph nodes was significant lower than that in Nlpositive nodes（ P = 0. 027） . There were no significant difference in the contents of all 7 elements between intestinal type and diffuse type （ P = 0. 149-0. 758, P 〉 0.05）. Conclusions Lymphatie metastasis of gastric cancer is coneomitant with the changes of trace elements, and the ehanges of Zn,Cu,Se may be related with lymphatic metastasis.

关 键 词：胃肿瘤 淋巴结 痕量元素 肿瘤转移 

分 类 号：R735.2[医药卫生—肿瘤]