瘤内注射^(90)Y-SAg治疗小鼠肝癌移植瘤的实验研究  

Experimental study of intratumor injection of ^(90)Y-SAg for the treatment of liver cancer in mice

作　　者：牟培源[1] 陈靖[2] 王建晨[2] 何千舸[2] 蒋小良[1] 金美娟[1] 李芳[1] 

机构地区：[1]解放军第二炮兵总医院超声诊断室,北京100088 [2]清华大学核研究院,北京102201

出　　处：《医学研究生学报》2006年第7期586-588,共3页Journal of Medical Postgraduates

基　　金：协合药业集团博士后科学基金资助项目(批准号:XHG20050601);全军医药卫生"十一五"科研基金资助项目(批准号:06MA038)

摘　　要：目的:探讨瘤内注射放射性核素钇-90(90Y)与超抗原(SAg)混悬液90Y-SAg治疗小鼠肝癌移植瘤的效果。方法:30只荷瘤小鼠随机分为三组,每组10只,分别瘤内注射0.1 m l SAg和0.1 m l(100μc i)90Y(A组)、0.1 m l(100μc i)90Y(B组)、0.1m l SAg(C组)。结果:注射后2周:B组、C组肿瘤生长率分别为0.18±0.12和0.21±0.17,两组差异不显著(P>0.05);A组呈负生长,生长率为-0.28±0.23,与B组和C组比较均有显著性差异(P<0.01);A、B、C三组肿瘤坏死率分别为0.36±0.18、0.11±0.09、0.10±0.06,B组和C组均为轻度坏死,两组间差异不显著(P>0.05),A组为中度坏死,与B组和C组比较有显著性差异(P<0.01)。结论:瘤内注射90Y-SAg疗效优于单一的90Y或SAg注射,是一种有效的治疗小鼠肝癌移植瘤方法。Objective ：To explore the effects of ^90Y-SAg injected directly into the tumors for the treatment of liver cancer in mice. Methods： Thirty Kunming mice with transplanted liver cancer were randomly injected respectively with ^90Y-SAg （group A）, ^90Y （group B）, and SAg（ group C）. Results： ^90Y concentrated in the tumor in group A and group B. No toxicity and no adverse side-effect were observed. In two weeks after the treatment, the lesions were reduced in size. The growth rate of tumor in group A （-0.28±0.23） was significantly different from those in group B （0. 18 ± 0. 12） and group C （0.21 ± 0.17 ）, although no significant difference existed between group B and group C （P 〉 0.05 ）. The differences of necrosis rates of tumors in all the three groups（0.36 ±0.18 in group A , 0.11±0.09 in group B and 0.10 ± 0.06 in group C ） had statistically shown the same results mentioned above. Conclusion： Intratumor injection of ^90Y-SAg is a safe, feasible and effective method to treat liver cancer in mice.

关 键 词：钇-90 超抗原 肝癌 注射 

分 类 号：R730.55[医药卫生—肿瘤]