重离子治疗肿瘤的两大优势  

Two Fascinating Advantages in Tumor Therapy with Heavy Ions

作　　者：郭传玲[1] 王菊芳[1] 金晓东[1] 魏巍[1] 李文建[1] 

机构地区：[1]中国科学院近代物理研究所,兰州中国科学院研究生院730000

出　　处：《肿瘤防治研究》2006年第7期477-479,共3页Cancer Research on Prevention and Treatment

基　　金：科技部重大基础前期研究专项基金(2003ccb00200);国家自然科学基金重点项目(100335050)

摘　　要：目的观察两种人恶性肿瘤细胞-人肝癌细胞SMMC-7721和人黑色素瘤细胞A375对高LET^12C^6＋离子和γ射线照射的敏感性及分次效应，观察重离子治疗肿瘤的可行性及优势。方法以两种体外培养的来源于人体不同组织的具有高辐射抗性的恶性肿瘤细胞为实验对象，分别进行^12C^6＋和γ射线0～6Gy内不同剂量点的单次和分次照射，采用克隆存活法统计细胞的存活分数。结果无论是单次还是分次照射，^12C^6＋照射后两种细胞的存活分数均明显低于γ射线照射的细胞，而且重离子的分次效应明显降低。结论结果显示重离子在肿瘤治疗中的两个重要优势，即具有高的肿瘤杀伤力和低的分次效应，显示重离子照射引发的低修复现象，可使肿瘤放疗具有更高的效率。Objective We should be wise to the feasibility and advantages of tumor therapy with heavy ions by observing the radiosensitivity and the effect of fractional irradiation of two kinds of malignant human tumor cell lines which were respectively irradiated with ^60Co γ-rays and ^12C^6＋ ions with high LET. Methods We chose two kinds of malignant human tumor cell line which derived from different tissues and had low radiosensitivity, namely A375 and SMMC-7721. After respectively irradiated with ^60Co γ- rays and ^12C^6＋ in dose range 0-6Gy, the survival fractions of single irradiation and fractional irradiation were studied by colony-formation assays. Results The results showed that： as to each cell lines involved in the assay, the survival fractions of cells irradiated with ^12C^6＋ were much lower than that of cells irradiated with γ-rays not only when singly irradiated but also when fractionally irradiated. Which was more fascinating was that the effect of fractional irradiation was impaired to both two cell lines when irradiated with ^12C^6＋. Conclusion The assay showed some captivating properties of ^12C^6＋ in tumor therapy that ^12C6＋ could kill tumor cells more efficiently than ）＇-rays, as well as ^12C6＋ may lead a weakened repair which would make the therapy more efficient.

关 键 词：肿瘤细胞 重离子 存活分数 

分 类 号：R730[医药卫生—肿瘤] Q691[医药卫生—临床医学]