放化疗结合治疗直肠癌术后复发  

Effecting Observation of Stereotactic Radiotherapy Combined with Chemotherapy for Postoperative Local Recurrent Rectal Cancer

作　　者：王鹏[1] 潘绵顺[1] 黄勇[1] 

机构地区：[1]合肥伽玛刀医院放射肿瘤中心,230022

出　　处：《肿瘤防治研究》2006年第7期524-526,共3页Cancer Research on Prevention and Treatment

基　　金：卫生部科研基金资助项目(WKJ-2005-3-006)

摘　　要：目的 探讨立体定向放射治疗结合化疗治疗直肠癌术后复发的疗效。方法 回顾性分析61例直肠癌术后复发患者行立体定向放射治疗（4-5Gy／次，4次／周，总剂量48～50Gy／10～12次，2～3周）结合化疗（5-Fu0．75g／m^2，d1～5；顺铂40mg／m^2，d1～3）的疗效，在第4周以后重复该化疗方案4～5周期，生存分析采用Kaplan-Meier法。结果 患者1、2、3年肿瘤局部控制率分别为86．9％、67．2％、37．7％；1、2、3年生存率分别为80．3％、62．3％、39．2％，中位生存期24．6个月；1、2、3年无瘤生存率分别为79．7％，52．5％、31．1％。急性放射性反应包括放射性肠炎和膀胱炎；晚期放射性反应包括放射性肠炎，骶丛炎和输尿管炎。结论 立体定向放射治疗结合化疗是治疗直肠癌术后复发的有效姑息治疗方法。Objective To evaluate the effects of stereotactic radiotherapy （SRT）combined with chemotherapy for rectal cancer of postoperative local recurrence. Methods Sixty-one rectal cancer patients of postoperative local recurrence were treated with SRT （4-5Gy daily fraction; 48-50Gy/2-3weeks） combined with chemotherapy （5-Fu 0. 75, Days 1-5 and Days 29-33; Cisplatin 40mg, Days 1-3 and Days 29- 31 ）. Acute and late radiation reactions and survival rates were observed. Kaplan-Meier method was used for survival analysis. Results The 1,2,3 years local control rate was 86. 9%, 67. 2%, 37. 7%, respectively. The 1,2, 3 years disease free survival and overall were 80. 3%,62.3%,39. 2%, and 79. 7%, 52. 5% ,31.1% ,respectively. The median survival was 24. 6 months. Radiation reaction were most acceptable Grade 1-2. No late radioreaction so occurred. Conclusion SRT combined with chemotherapy can be used as an effective and feasible approach to cancer patients of postoperative local recurrence.

关 键 词：直肠肿瘤 肿瘤复发 局部 立体定向放射治疗 

分 类 号：R735.37[医药卫生—肿瘤]