噻奈普汀与丙咪嗪治疗老年抑郁症对照研究  

A control study of Tianeptine and imipramine in the treatment of elderly depressive patients

作　　者：韩海英[1] 陆小兵[1] 杨东英[1] 沐楠[1] 姚建新 

机构地区：[1]广州市精神病医院精神科,510370 [2]广州市萝岗区康宁医院精神科

出　　处：《神经疾病与精神卫生》2006年第3期188-189,共2页Journal of Neuroscience and Mental Health

摘　　要：目的 观察噻奈普汀治疗老年抑郁症的疗效和安全性。方法随机将60例年龄≥60岁的老年抑郁症患者分为丙咪嗪组（30例）和噻奈普汀组（30例），疗程6周，采用汉密尔顿抑郁量表（HAMD）和剐反应量表（TESS）在治疗前和治疗后1、2、4、6周末评定药物疗效和副反应。结果两组疗效无显著差异，HAMD总分及各因子分从疗后2周～6周均较治疗前显著降低，两组同比较无显著性差异，治疗结束时TESS评分噻奈普汀组显著低于丙咪嗪组。结论噻奈普汀疗效好，副反应少，适合于老年抑郁症特别是伴有躯体疾病患者的治疗，服用方便、安全，可首选使用。Objective To study the efficacy and safety of tianeptine in the treatment of elderly depressive patients. Methods 60 elderly depressed patients were randomized into tianeptine group （ n=30） and imipramine （n=30） group. The patients received treatment for 6 weeks. HAMD and TESS were used to assess the efficacy and side effects before and after 1week, 2 weeks, 4 weeks and 6weeks of treatment. Results There was no significant difference in efficacy between the two groups. HAMD scores and the factor scores from week 2 to week 6 decreased dramatically as compared to those pretreatment. No significant difference was observed between the two groups. After the trial the TESS scores in tianeptine group were significantly lower than those of imipramine group. Conclusions Tianeptine was an effective, convenient and safe treatment in elderly depressive patients and especially suitable to the patients with somatic diseases.

关 键 词：抑郁症 老年 噻奈普汀 丙咪嗪 

分 类 号：R749.4[医药卫生—神经病学与精神病学]