硒蛋白P在结肠癌组织中的表达及其意义  

Expression and significance of selenoprotein P in colon carcinoma tissues

作　　者：鲁建国[1] 王青[1] 马庆久[1] 宁力[2] 房青[2] 褚延魁[1] 杜锡林[1] 杨媛[1] 林晨[2] 

机构地区：[1]第四军医大学唐都医院普通外科,陕西西安710038 [2]协和医科大学肿瘤研究所分子肿瘤学国家重点实验室,北京100021

出　　处：《第四军医大学学报》2006年第14期1328-1330,共3页Journal of the Fourth Military Medical University

摘　　要：目的:研究结肠癌组织中硒蛋白P的表达及其意义.方法:选用手术切除结肠癌组织30例,同时另取30例正常结肠组织作为对照,用免疫组化的方法观察硒蛋白P在结肠癌组织中的表达.结果:硒蛋白P在结肠癌组织中的阳性表达率(60.0%)低于其在正常结肠组织中的表达率(80.0%),二者相差有统计学意义(P<0.05);硒蛋白P在高、中分化病例中表达率(86.7%)高于低分化例病例中表达率(33.3%),二者相差有统计学意义(P<0.05);硒蛋白P在Ⅰ～Ⅱ期病例中表达率为58.8%,Ⅲ期病例中表达率为61.5%,二者相差无统计学意义(P>0.05).结论:硒蛋白P在结肠癌组织中为低表达,与肿瘤的分化程度有关,与肿瘤的TNM分期无关.AIM： To investigate the expression and significance of selenoprotein P in colon carcinoma tissues. METHODS： Samples were derived from 30 cases of colon carcinoma, and 30 corresponding normal colon tissues were used as controls. The expression of selenoprotein P in colon carcinoma tissues were investigated by immuohistochemical stain. RESULTS： The expression rate of selenoprotein P in colon carcinoma （60.0%） was significantly lower than that of their control normal tissues （80.0%, P 〈0.05）. The expression rate of selenoprotein P in high- and on cases（86.7% ） was higher than that of lower-differentiation tissues （33.3%, P 〈 0. 05 ）. The expression rate of selenoprotein P was 58.8% in Ⅰ-Ⅱ stage cases, and 61.5% in Ⅲ stage cases（ P 〉 0.05 ）. CONCLUSION： The expression which of selenoprotein P is low in colon carcinoma tissues, which is related with differentiation levels of colon carcinoma, but not with TNM stage of tumor.

关 键 词：肿瘤/病理学 蛋白质类/分析 硒 免疫组织化学 

分 类 号：R730.2[医药卫生—肿瘤]