肺癌、肺挫伤及急性肺炎患者血清细胞因子水平测定及其临床意义  

Comparison of serum cytokines levels in patients with lung cancer, pulmonary contusion and acute pneumonia

作　　者：王也玲[1] 范敏明[1] 

机构地区：[1]浙江大学医学院附属第二医院,杭州310009

出　　处：《浙江医学》2006年第7期532-533,共2页Zhejiang Medical Journal

摘　　要：目的检测肺癌、肺挫伤及急性肺炎患者血清可溶性白介素-2受体(sIL-2R)、肿瘤坏死因子(TNF-α)和白介素-6(IL-6)水平并探讨细胞因子在3类疾病中的意义。方法选择未经治疗、无并发症的肺癌患者24例、肺挫伤患者21例、急性肺炎患者33例及正常成人25例。采用ELISA法测定血清sIL-2R、TNF-α和IL-6的含量。结果各组患者血清细胞因子含量均明显高于正常者,但3类疾病间的增高程度不同(P<0.05)。sIL-2R的增高依次为肺癌>急性肺炎>肺挫伤,TNF-α和IL-6的增高均依次为急性肺炎>肺挫伤>肺癌。结论血清细胞因子水平升高程度的不同造成不同程度的炎症和免疫反应,3类疾病均存在不同程度的免疫抑制,以肺癌患者免疫抑制最为明显,提示对此类患者应重视增强免疫治疗。Objective To detect the serum cytokines levels of slL-2R,TNF-α and IL-6 in patients with lung cancer,pulmonary contusion and acute pneumonia and discuss the significance of cytokines in these diseases. Methods The serum levels of slL-2R, TNF-α and IL-6 were measured by ELISA method in 24 patients with lung cancer, 21 patients with pulmonary contusion, 33 patients with acute pneumonia and 25 healthy adults （control group）. Results Serum cytokines levels in each disease group were significantly higher than those in the normal control group. Level of sIL-2R in patients with lung cancer was the highest compared with that in acute pneumonia and pulmonary contusion （lung cancer 〉 acute pneumonia 〉pulmonary contusion）. Serum TNF-α and IL-6 levels in acute pneumonia patients were higher than those in pulmonary contusion and lung cancer patients （acute pneumonia〉 pulmonary contusion 〉lung cancer）. Conclusion Lung cancer, pulmonary contusion and acute pneumonia have various serum slL-2R, TNF-α and IL-6 levels, which indicates the immunological and inflammatory response in these diseases.

关 键 词：肺癌 肺挫伤 肺炎 细胞因子 

分 类 号：R734.2[医药卫生—肿瘤] R655[医药卫生—临床医学] R563.1