七-(2,6-二-O-甲基)-β-环糊精对1,1'-联萘酚对映体手性识别的电喷雾质谱研究  

Investigation of Chiral Recognition of 1,1'-Bi-2-naphthol Enantiomers by Heptakis-(2,6-di-O-methyl)-β-cyclodextrin with Electrospray Mass Spectrometry

作　　者：于湛[1] 闫存玉[1] 宋凤瑞[1] 刘志强[1] 刘淑莹[1] 

机构地区：[1]中国科学院长春应用化学研究所新药研究实验室

出　　处：《化学学报》2006年第14期1507-1512,共6页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20273067)资助项目.

摘　　要：利用电喷雾质谱研究了β-环糊精、七-(2,6-二-O-甲基)-β-环糊精作为手性识别试剂对1,1'-联萘酚对映体的手性识别效应.实验结果表明,在气相中,β-环糊精与七-(2,6-二-O-甲基)-β-环糊精都可以与联萘酚形成非共价复合物.对形成的复合物的串联质谱研究表明,β-环糊精不能识别联萘酚对映体,而七-(2,6-二-O-甲基)-β-环糊精对联萘酚对映体有较强的手性识别效应.进一步研究表明七-(2,6-二-O-甲基)-β-环糊精与联萘酚对映体混合比例以及CID能量对于手性识别并无影响.Chiral recognition of enantiomeric 1,1＇-bi-2-naphthol enantiomers by β- and heptakis-（2,6-di-O- methyl）-β-cyclodextrins as chiral selectors was investigated by electrospray mass spectrometry. Comparative research shows that both β-cyclodextrin and heptakis-（2,6-di-O-methyl）-β-cyclodextrin can form noncovalent complexes with 1,1＇-bi-2-naphthol in gas phase. Investigation of tandem mass spectrometric data displays that β-cyclodextrin has little chiral recognition ability to the enantiomers but heptakis-（2,6-di-O- methyl）-β-cyclodextrin has strong chiral recognition ability. Our work also displays that mixing ratio of heptakis-（2,6-di-O-methyl）-β-cyclodextrin to 1,1＇-bi-2-naphthol and the collision induced disossiation energy have no effect on chiral recognition.

关 键 词：手性识别 环糊精 联萘酚 电喷雾离子化 非共价复合物 

分 类 号：O657.63[理学—分析化学]