KNSL4基因的结构及生物学功能  

Structure and Biological Function of KNSL4 Gene

作　　者：王玉丽[1] 冯玉梅[2] 

机构地区：[1]天津医科大学附属肿瘤医院肿瘤研究所生物化学和分子生物学室,天津市300060 [2]天津医科大学附属肿瘤医院乳腺癌防治教育部重点实验室,天津市300060

出　　处：《医学分子生物学杂志》2006年第4期275-278,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.30471671)~~

摘　　要：驱动蛋白样DNA结合蛋白(kinesinlikeDNAbindingprotein,KNSL4)基因是驱动蛋白(kinesin)基因家族中的成员。KNSL4基因及其蛋白产物Kid的分子结构和在促有丝分裂中影响纺锤体形成、维持纺锤体形态、驱动染色体列队和分离的功能已为大量研究结果所证实;Kid直接作用于cerbB2基因的启动子区域的顺式作用元件,也可能通过相连基因MAZ间接调控cMyc基因的转录,KNSL4基因的表达量与性激素依赖的肿瘤细胞增殖、血管内皮细胞生长因子(VEGF)和肝细胞生长因子(HGF)的促血管生成等成正相关。Kinesin-like DNA binding protein, KNSL4, belongs to the kinesin-like protein gene family. KNSL4 and its protein product, kid has been proved to influence the spindle formation, maintain spindle shape and drive the congression and segregation of chromosomes. Kid directly works on cis-acting element in promoter region of c-erbB-2, and possibly indirectly controls the transcription of c-myc via its neighboring gene MAZ. The expression of KNSL4 is positively related to the proliferation of sex hormone dependent tumor cells, and to the angiogenesis of VEGF and HGF. However, no report has been reported concerning the kid-mediated biological functions in the development and progression of tumors and its mechanism in histopathological changes.

关 键 词：KNSL4 有丝分裂 肿瘤 

分 类 号：Q730.2[生物学—分子生物学]