肝硬化患者PT、APTT、FIB、TT及D-D参数变化的初步探讨  

Exploration on changes of PT,APTT,FIB,TT and D-D in patients with cirrhosis

作　　者：李志方[1] 邓小燕[1] 

机构地区：[1]广州医学院第二附属医院检验科,广州510260

出　　处：《广州医药》2006年第4期47-48,共2页Guangzhou Medical Journal

摘　　要：目的研究肝硬化患者凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)、血浆凝血酶时间(TT)及D-二聚体(D-D)的变化及临床意义。方法应用全自动血凝仪和全自动生化仪检测各组血浆中PT、APTT、FIB、TT及D-D值。结果肝硬化患者与对照组比较PT、APTT、TT及D-D均明显延长而FIB则明显下降,两者比较差异有显著性(P<0.01)。结论肝硬化患者血浆凝血及纤溶实验(PT、APTT、FIB、TT及D-D)各参数均有变化,可从多方面客观准确地评价肝硬化患者凝血功能状况及其病情预后。Objective To explore the changes and significance of PT, APTT, FIB, TT＂ and D-D in patients with cirrhosis. Methods PT, APTT＇, FIB, TT＂ and D-D were measure by full-antomatic instrument. Results The PT, APTT＇, TT＂ and D-D obviously prolong but the FIB obviously descend, those patients indices showed the significant difference in compared with normal control subjects （ P 〈 0. 01 ） . Conclusion The changes of PT, APTI＇, FIB, TI＂ and D-D in patients with cirrhosis are determined, these indices can be used to evaluate the coagulation bloods fundtion and prognosis.

关 键 词：肝硬化 凝血酶原时间 活化部分凝血酶原时间 血浆纤维蛋白原 血浆凝血酶时间 D-二聚体 参数 

分 类 号：R575.2[医药卫生—消化系统]