熊脱氧胆酸缓解硫唑嘌呤和皮质激素耐药的I型自身免疫性肝炎  

Remission with ursodeoxycholic acid of type 1 autoimmune hepatitis resistant to azathioprine and steroids

作　　者：Duclos-Vallée J.-C. Di Martino V. Cazier A. 成虹 

机构地区：[1]Centre Hépato-Biliaire and UPRES 3541, Hpital Paul Brousse, 14 avenue Paul Vaillant Couturier, 94804 Villejuif

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第6期25-25,共1页Core Journals in Gastroenterology

摘　　要：Combination therapy with steroids and azathioprine is the reference treatment for autoimmune hepatitis, but potential adverse effects are numerous and intolerance can occur. We report a patient with a well-documented type 1 autoimmune hepatitis intolerant to corticosteroids and azathioprine therapy, in whom eight years of ursodeoxycholic acid monotherapy was associated with biochemical and histological remission.Combination therapy with steroids and azathioprine is the reference treatment for autoimmune hepatitis, but potential adverse effects are numerous and intolerance can occur. We report a patient with a well-documented type 1 autoimmune hepatitis intolerant to corticosteroids and azathioprine therapy, in whom eight years of ursodeoxycholic acid monotherapy was associated with biochemical and histological remission.

关 键 词：Ⅰ型自身免疫性肝炎 熊脱氧胆酸 硫唑嘌呤 皮质激素 激素耐药 胆酸治疗 联合疗法 肝炎患者 不良反应 

分 类 号：R575.1[医药卫生—消化系统] R575.05[医药卫生—内科学]