采用Levovist增强的血管后相超声对肝硬化结节性病变进行鉴别诊断:与超顺磁性氧化铁增强的磁共振成像的对比研究  

Differential diagnosis of nodular lesions in cirrhotic liver by post-vascular phase contrast-enhanced US with Levovist:Comparison with superparamagnetic iron oxide magnetic resonance images

作　　者：Inoue T. Kudo M. Watai R. 郝筱倩(译) 陈云茹(校) 

机构地区：[1]不详 [2]Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine,377 -2 Ohno-Higashi, Osaka-Sayama 589-8511,Japan

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第6期46-47,共2页Core Journals in Gastroenterology

摘　　要：Background: We investigated the diagnostic utility of post-vascular phase contrast-enhanced ultrasonography (US) and superparamagnetic iron oxide (SPIO)enhanced magnetic resonance imaging (MRI) as compared to the histological diagnosis of differential grades of hepatocellular carcinomas (HCCs). Methods: Forty-nine patients with histologically characterized liver nodules (well-differentiated HCC, n = 20; moderately differentiated HCC, n = 19; poorly differentiated HCC, n = 1; dysplastic nodule, n = 9) received contrast-enhanced US and SPIO-MRI. Subsequently, we quantitatively evaluated the relationships between the images of the nodules and their histological diagnosis and differential grades. Results: The ratio of the echogenicity of the tumorous area to that of the nontumorous area with post-vascular phase contrast-enhanced US (post-vascular phase ratio) decreased as nodules became less differentiated (P < 0.05; Kruskal-Wallis test). The ratio of the intensity of the nontumorous area to that of the tumorous area on SPIO-enhanced MR images (SPIO intensity index) also decreased as nodules became less differentiated (P < 0.01). The post-vascular phase ratio correlated with the SPIO intensity index for HCCs and dysplastic nodules (r = 0.76). The conformity of the result from the post-vascular phase contrast-enhanced US and SPIO-MRI was 96%. Conclusions: Contrast-enhanced US is a valuable method for predicting the histological grade of HCCs in cirrhotic patients, and may be a good alternative to SPIO-enhanced MRI.Background：We investigated the diagnostic utility of post-vascular phase contrast-enhanced ultrasonography （US） and superparamagnetic iron oxide （SPIO） enhanced magnetic resonance imaging （MRI） as compared to the histological diagnosis of differential grades of hepatocellular carcinomas （HCCs）. Methods： Forty-nine patients with histologically characterized liver nodules （well-differentiated HCC, n = 20; moderately differentiated HCC, n = 19; poorly differentiated HCC, n = 1; dysplastic nodule, n = 9） received contrast-enhanced US and SPIO-MRI. Subsequently, we quantitatively evaluated the relationships between the images of the nodules and their histological diagnosis and differential grades. Results： The ratio of the echogenicity of the tumorous area to that of the nontumorous area with post-vascular phase contrast-enhanced US （post-vascular phase ratio） decreased as nodules became less differentiated （P 〈 0. 05; Kruskal-Wallis test） . The ratio of the intensity of the nontumorous area to that of the tumorous area on SPIO-enhanced MR images （SPIO intensity index） also decreased as nodules became less differentiated （P 〈 0.01）.

关 键 词：超顺磁性氧化铁增强 结节性病变 磁共振成像 肝硬化患者 鉴别诊断 血管 超声 SPIO增强 组织学诊断 

分 类 号：R735.7[医药卫生—肿瘤] R563[医药卫生—临床医学]