促性腺激素释放激素激动剂或拮抗剂治疗时,卵母细胞成熟度和植入前发育与卵泡直径的关系  

Oocyte maturity and preimplantation development in relation to follicle diameter in gonadotropin-releasing hormone agonist or antagonist treatments

作　　者：Nogueira D. Friedler S. Schachter M. 朱磊 

机构地区：[1]Women and InfantsHospital, NewEnglandMedical Center, Tufts, Box 036, 750Washington Street, Boston, MA, United States,Dr.

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2006年第6期30-30,共1页Core Journal in Obstetrics/Gynecology

摘　　要：Objective: To analyze the distribution of oocytes nuclear maturational stages and intracytoplasmic sperm injection (ICSI) outcome in relation to follicular size, after controlled ovarian hyperstimulation (COH), using gonadotropin- releasing hormone (GnRH) antagonist or agonist protocols. Design: Prospective comparative study. Setting: Fertility unit in an academic hospital. Patient(s): Normo- ovulatory patients with unexplained, male and/or tubal factor infertility undergoing ICSI treatment. Intervention(s): Oocytes were retrieved from small (7- 12 mm) and large follicles (>12 mm). Main Outcome Measure(s): Oocyte nuclear maturation stage, fertilization and preimplantation embryonic development of the mature ova evaluated. Result(s): Distribution of oocyte maturation stages from small follicles did not differ between the two COH protocols. From large follicles, a statistically significantly higher percentage of immature oocytes was retrieved after antagonist compared with agonist treatment (16 vs 11% , respectively). No statistically significant differences existed regarding ICSI outcome of mature ova within the same follicle diameter range between COH protocols. Inseminated ova from small follicles presented a significantly higher number of embryos with delayed development on day 3 after ICSI. Conclusion(s): A greater heterogeneity of maturity was found in the population of oocyte stages that were present after the antagonist protocol. Matured oocytes retrieved from small follicles generated embryos of lower developmental potential than oocytes derived from larger follicles.Objective： To analyze the distribution of maturational stages and intracytoplasmic oocytes nuclear sperm injection （ICSI） outcome in relation to follicular size, after controlled ovarian hyperstimulation （COH）, using gonadotropin-releasing hormone （GnRH） antagonist or agonist protocols. Design： Prospective comparative Setting： Fertility Normo-ovulatory unit in an academic hospital. study. Patient （s） ： patients with unexplained, male and/or tubal factor infertility undergoing ICSI treatment. Intervention（s）： Oocytes were retrieved from small （7 - 12 mm） and large follicles （〉 12 mm） . Main Outcome Measure （s）： Oocyte nuclear maturation stage, fertilization and preimplantation embryonic development of the mature ova evaluated. Result（s）： Distribution of oocyte maturation stages from small follicles did not differ between the two COH protocols. From large follicles, a statistically significantly higher percentage of immature oocytes was retrieved after antagonist compared with agonist treatment （16 vs 11%, respectively）.

关 键 词：促性腺激素释放激素激动剂 卵母细胞单精子显微注射 GNRH拮抗剂 卵泡直径 成熟度 发育 治疗 植入前 控制性超排卵 ICSI 

分 类 号：R711.71[医药卫生—妇产科学] R321[医药卫生—临床医学]