准分子激光屈光性角膜切削术中应用丝裂霉素C预防角膜上皮下雾状混浊形成的meta分析  

Meta-analysis of prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy

作　　者：吴荒[1] 王春勇[2] 王宜[1] 宋跃[1] 郑雅娟[1] 

机构地区：[1]吉林大学第二医院眼科,吉林长春130041 [2]吉林大学公共卫生学院流行病学教研室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2006年第4期683-686,共4页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(30571993);长春市科技局资助课题(03-1188527)

摘　　要：目的：探讨在准分子激光屈光性角膜切削术（PRK）中应用丝裂霉素C对抑制角膜上皮下雾状混浊（haze）形成的效果。方法：检索Medline、OVID医学期刊全文数据库、中国学术期刊全文库、万方数据资源系统收录的1995年4月-2005年4月10年发表的关于丝裂霉素C与PRK相关的对照研究，并辅以手工检索。结果：共纳入2项随机对照试验，异质性Q检验无统计学差异（χ^2=0．17，df=1，P=0．68）。2项研究的OR值分别为0．17[95％CI0．05～0．533、0．10[95％CI0．01～0．853；合并OR值为0．14[95％CI0．05～0．403，与对照组比较差异有显著性（Z=3．75，P=0．0002）。结论：PRK术中局部应用0．02％丝裂霉素C可以明显减少高度近视眼术后的haze形成。Objectivo To evaluate the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy （PRK）. Mothocls Both a computer-aided search of Medline, OVID, CNKI, Wanfang data and an intensive search by hand were conducted to identify all randomized controlled trials assessing the effect of intraoperative using mitomycin-C during PRK. Results Two studies were finally included. The Q test of homogeneity showed no difference between them （χ^2 =0. 17, dr= 1, P=0.68）. The OR value of the studies were 0. 17 [95% CI 0.05-0. 53] and 0. 10 [95% CI 0. 01-0.85], respectively; the pooled OR was 0. 14 [95% CI 0. 05-0. 40], significant difference was found between experimental group and control group （Z= 3.75, P=0. 000 2）. Conclusion Topical intraoperative application of 0. 02% mitomyein-C can reduce haze formation in patients with highly near-sightedness after PRK.

关 键 词：丝裂霉素/治疗作用 角膜切除术 光折射 准分子激光/方法 角膜上皮下雾状混浊 综合分析 

分 类 号：R779.63[医药卫生—眼科]