超敏C反应蛋白与脑梗死病情演变的关系  

The relationship between high-sensitivity C-reactive protein and the progress of cerebral infarct

作　　者：黄宗青[1] 叶志中[2] 刘素英[1] 李爱东[1] 刘洪涛[1] 张志[1] 张小燕[1] 史少凤[1] 谭琦[3] 

机构地区：[1]广东医学院附属福田人民医院神经科,深圳518033 [2]广东医学院深圳风湿病研究所 [3]中山大学东华医院神经科

出　　处：《中国药物与临床》2006年第7期488-489,共2页Chinese Remedies & Clinics

基　　金：广东省医学科学技术研究基金资助项目(A2001798)

摘　　要：目的探讨早期超敏C反应蛋白(hs-CRP)含量与脑梗死病情进展的关系。方法对经头颅CT或磁共振成像(MRI)证实的急性缺血性脑梗死患者于发病24h内与7d采用化学发光免疫法测定hs-CRP,采用加拿大卒中量表对发病后48h病情发展变化进行评定,根据评分结果分为进展性与非进展性脑梗死两组。结果进展性脑梗死患者血清hs-CRP水平明显高于非进展性患者(P<0.01),发病后24h的血清hs-CRP水平高于7d的水平(P<0.01)。结论hs-CRP与脑梗死所致神经功能损害程度密切相关,早期检测可以为脑梗死的病情变化提供有用的信息。Objective To study the relationship between high sensitive C-reactive protein （hs-CRP） and the progress of cerebral infarct. Methods The levels of hs-CRP were measured in 24 hours and seven days after using chemiluminescence immunoassay in the patients of acute isehemie stroke who were diagnosed hy CT or MRI. The disease progress were valued by Canadian neurologieal seale in 48 hours after eerebral isehemie stroke.The patients were divided into progressing group and no-progressing group. Result The serum levels of hs-CRP in the progressing group were significantly higher than that in the no-progressing group （P〈0.01）. The serum levels of hs-CRP in 24 hours were significantly higher than that after 7 days（P〈0.01 ）. Conclusion The level of hs-CRP is closely associated with the degree of the neurological damage caused by isehemie stroke. It can provide useful information for cerebral infarct.

关 键 词：脑梗死 超敏C反应蛋白 炎症 进展性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]