肝动脉化疗栓塞及瘤体内注射化疗药物、乙酸治疗原发性肝癌  

Therapeutic efficacy of TACE and percutaneous intratumoral injection ofchemotherapeutics and acetic acid in primary liver cancer

作　　者：陈宏斌[1] 黄跃[1] 黄醇[1] 黄种文[1] 张起楷[1] 王慧华[1] 张俊苏[1] 潘革[1] 

机构地区：[1]福建省三明市第一医院,365000

出　　处：《中华腹部疾病杂志》2006年第7期475-477,共3页Chinese Journal of Celiopathy

摘　　要：目的研究肝动脉化疗栓塞及CT或B超引导下瘤体内注射化疗药物、乙酸治疗原发性肝癌的临床价值。方法选择33例中晚期肝癌分为两组，18例单纯应用肝动脉化疗栓塞（TACE）治疗，15例采用综合治疗（TACE＋瘤体内注射化疗药物及乙酸）。结果综合治疗组肿瘤缩小率、AFP下降率分别为86．6％、83．3％，而单纯TACE组分别为55．6％及40％，两组比较有显著性差异（P〈0．01）。1、2、3、4年生存率综合治疗组分别为96．7％、86．6％、51．3％、33．3％，而单纯治疗组分别为66．7％、444％、167％、0％，两组比较亦有显著性差异（P〈0．01）。结论TACE＋瘤内注射化疗药物及乙酸综合治疗是提高中晚期厚发性肝癌生存率的有效方法。AIM To study the clinical efficacy of transcatheter arterial chemoembolization（YAOE） combined with percutaneous intratumoral injection of chemotherapeutics and acetic acid in the treatment of primary liver cancer （PLO）. METHODS Thirty- three patients with intermediate - or advanced - stage PLO were treated with TACE（n = 18）or TAOE plus subsequent percutaneous intratu- moral injection of acetic acid and 5 - FU （n = 15）. RESULTS Tumor size was reduced in 86.6% and serum AFP was decreased in 83.3 % patients receiving TACE and intratumoral injection, both more frequently than those in patients receiving TACE only, which were 55.5 % and 40.0 %, respectively（ P 〈 0.01）. The 1 -, 2 -, 3 - and 4 - year survival rates were 96.7 %, 86.6 %, 51. 3 % and 33.3% for the former group,66.7% ,44.4% ,16.7% and 0% for the latter group,respectively（ P 〈0.01）.CONCLUSION Percutaneous intratumoral injection of chemotheraputics and acetic acid has supplemental effects to TAOE in the treatment of primary liver cancer.

关 键 词：原发性肝癌 肝动脉化疗栓塞 肝动脉 乙酸 瘤体内化疗药物注射 

分 类 号：R735.7[医药卫生—肿瘤]