抑制血清TNF-α对大鼠脂肪肝的影响的实验研究  

Effect of TNF alpha inhibition in rat with fatty liver.

作　　者：张瑞红[1] 黄振宇[2] 张雯[2] 钱绍诚[3] 

机构地区：[1]天津市天和医院消化内科 [2]天津医药职工大学 [3]天津市第三中心医院,天津300050

出　　处：《临床和实验医学杂志》2006年第8期1069-1070,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的观察肿瘤坏死因子-a抑制剂己酮可可碱,对乙醇及高脂饮食诱导造模的大鼠脂肪肝形成的影响。方法将24只大鼠分成对照组、造模组和己酮可可碱组(PTX组)三组,造模组、PTX组采用乙醇及高脂饮食诱导进行脂肪肝造模,同时分别给予蒸馏水、己酮可可碱预防治疗12周。治疗后测定各参数及肝脏病理检查。结果PTX组大鼠血清TNF-a、ALT、AST浓度及肝脂的含量、肝病理脂肪化程度均低于造模组(P<0.05)。结论肿瘤坏死因子-a抑制剂己酮可可碱能有效防治大鼠脂肪肝形成。Objective To determine if pentoxifyUine （PTX） ,α TNF - alpha inhibition, attenuates alcoholic and high fat diet induced steato- hepatitis in rat. Methods Rats were placed or control diet forl2 weeks and were treated with or without PTX. Then, serum TNF - α, ALT, AST, TG , liver TG and liver histology were evaluated. Results Serum TNF - α , ALT, AST levels, hepatic triglyceride content were reduced and liver histologic evidence of steatosis had decreased in the PTX group compared to the model group. （ P 〈 0.05 ）. Conclusion This study suggested that pentoxifylline suppresses hepatic steatosis in rat and it is suggested to try using the drug in treatment of fatty liver patients .

关 键 词：脂肪肝 已酮可可碱 肿瘤坏死因子-Α 

分 类 号：R575.5[医药卫生—消化系统]