全脑放疗同步VM26+DDP化疗治疗肺癌脑转移  

Concomitant Whole Brain Radiotherapy and VM26+DDP Chemotherapy in Brain Metastasis of Lung Cancer

作　　者：兰琼玉[1] 刘安文[1] 胡蓉环[1] 蒋为明[1] 

机构地区：[1]南昌大学第二附属医院肿瘤科,江西南昌330006

出　　处：《实用临床医学（江西）》2006年第7期24-26,共3页Practical Clinical Medicine

摘　　要：目的：评价全脑放疗同步VM26＋DDP化疗治疗肺癌脑转移的近期疗效和毒性。方法：全脑照射剂量30Gy，每次3Gy，5次／周，或40Gy．每次2Gy．5次／周。化疗DDP20mg／m^2．静脉滴注．连续4d；VM2660mg／m^2．静脉滴注．连续3d．3～4周为1周期。全脑放疗5次后开始同步化疗。放疗结束并完成2周期化疗后复查头部CT或MRI评价疗效。结果：全组38例肺癌脑转移患者均完成全脑放疗及2周期化疗。脑转移灶有效率68．4％，CR11例（28．9％），PR15例（39．5％）。结论：全脑放疗同步VM26＋DDP化疗治疗肺癌脑转移疗效较好．毒副反应不大，患者可耐受．Objective： To evaluate the efficacy and toxicity of concomitant chemoradiotherapy in patients with brain metastasis from lung cancer. Methods：Thirty-eight patients suffering from lung cancer with brain metastasis were included in this study. Treatment consisted of concomitant whole brain radiotherapy（WBRT） with a dose of 30 Gy in 10 fractions or 40 Gy in 20 fractions. Concomitant chemotherapy of VM26＋DDP regimen with teniposid 60 mg/m^2 on dl to d3,cisplatin 20 mg/m^2 on dl to d4, repeating every 3 or 4 weeks. The response was evaluated by CT or MRI after WBRT and 2 cycles of chemotherapy was completed. Results：ALL patients completed WBRT and concomitant chemotherapy. The response rate of brain disease was 68.4% with CR for 11 patients （28. 9%） and PR for 15（39.5%）. Conclusion：Concomitant WBRT and VM26＋DDP chemotherapy can be performed for the patients with brain metastasis from lung cancer with a remarkable response rate.

关 键 词：肺癌 脑转移瘤 全脑放疗 化疗 

分 类 号：R734.2[医药卫生—肿瘤]