学习记忆能力与齿状回神经干细胞增殖的关系研究  

THE RELATIONSHIP BETWEEN LEARNING AND MEMORY AND THE PROLIFERATION OF NEURAL STEM CELLS IN THE DENTATE GYRUS

作　　者：杨伯宁[1] 周三国[1] 谭国鹤[1] 龚健古[1] 蓝玲[1] 

机构地区：[1]广西医科大学人体解剖学教研室,南宁530021

出　　处：《神经解剖学杂志》2006年第4期404-408,共5页Chinese Journal of Neuroanatomy

基　　金：广西省科学基金(桂科基0575058);广西医科大学科研基金(302052)资助项目

摘　　要：本研究旨在探讨学习记忆能力与齿状回神经干细胞增殖之间的关系。将成年雄性昆明小鼠随机分为水迷宫训练组和对照组,水迷宫训练组,又根据小鼠找到平台时间的长短,分为学习记忆能力强和学习记忆能力较弱二组。在水迷宫训练后的第1、7、14d,分别检测三组小鼠齿状回神经干细胞的增殖情况。结果表明,学习能力弱的小鼠,其齿状回神经干细胞增殖的数目与对照组相比较,无显著性差异;而学习记忆能力较强的小鼠,其齿状回神经干细胞增殖的数目显著多于学习记忆能力较弱及对照组的小鼠,并且增殖细胞的存活时间也比学习记忆能力较弱的小鼠长。结果提示,水迷宫训练并不能使所有的个体脑内神经干细胞增多,记忆能力的强弱与齿状回的神经干细胞增殖之间呈正相关。The present study was designed to investigate the relationship between the ability of learning and memory and the proliferation of the neural stem cells （NSCs） in the dentate gyrns, Adult male mice were randomly divided into water maze training and non-water maze training groups （control）. Then the mice of water maze training group were divided into high learning ability group and poor learning ability group according to their performance of the water maze training. At the end of 1,7 and 14 d after the training respectively, we detected the proliferation of NSCs in the dentate gyrus of three groups. The results show that there was not different in the number of new NSCs between the poor ability group and control group. However, the number of NSCs was more in high ability group than that in poor ability group and control group. Furthermore the survival time of new NSCs in high ability group was longer than that in other two groups. Our results suggest that the water maze training can not increase the proliferation.of NSCs in all individuals. There exists a positive correlation between the memory ability and the proliferations of the NSCs in dentate gyrns.

关 键 词：学习记忆 水迷宫 神经干细胞 增殖 齿状回 小鼠 

分 类 号：R33[医药卫生—人体生理学]