胸苷磷酸化酶检测在乳腺癌病人个体化化疗中的应用  

Application of thymidine phorylase test in tailoredua chemotherapy in the patients with breast cancer

作　　者：吴常青 谷俊朝[2] 

机构地区：[1]河南省平舆县中心医院,河南平舆463400 [2]首都医科大学附属北京友谊医院普外科,北京100020

出　　处：《现代肿瘤医学》2006年第8期957-958,共2页Journal of Modern Oncology

摘　　要：目的：探讨胸苷磷酸化酶（thymidine phosphorylase TP）检测在乳腺癌病人化疗中的应用价值。方法：2003年3月-2005年2月对85例可手术女性乳腺癌病人采用CTX＋卡培他滨方案的新辅化疗3个周期，化疗结束后评估临床疗效并行乳腺癌根治术，标本行TP检测，分析化疗疗效与TP表达的关系。结果：TP阳性者64例，化疗有效率71.78％；TP阴性者21例，化疗有效率28.57％（P〈0.01）。结论：TP检测对乳腺癌病人个体化化疗具有指导性意义。Objective： To investigate the correlation between thymidine phosphrylase （TP） expression and respense to chemotherapy in patients with breast cancer. Methods： From March 2003 to February 2005, 85 cases of operable primary breast cancer patients had received chemotherapy with ctx ＋ xeloda regimen for 3 cycles. Clinic effect was evalauated and operation was performed after chemotherapy. Specimen were examined by TP test, to investigate the correlation between TP expression and response to chemotherapy. Results： Sixty four cases were TP positive , chemotherapy effectivre rate was 71.78% ;21 cases TP negative, chemotherapy effective rate was 28.75% （P〈0.01 ）. Conclusion： The expression of TP can be an important marker in selecting chemotherapy regimen and predicting the efficacy of chemotherapy for breast cancer patients.

关 键 词：乳腺肿瘤 化疗 胸苷磷酸化酶 

分 类 号：R737.9[医药卫生—肿瘤]