^(153)Sm-EDTMP联合宜利治改善晚期恶性肿瘤骨转移患者生活质量的临床研究  

Clinical study on ^(153)Sm-EDTMP combined with Yilizhi for improvement of the quality of life(QOL) in patients with terminal osteoid metastasis

作　　者：黄瑞文[1] 陈思现[1] 李勇[1] 

机构地区：[1]广东省农垦中心医院肿瘤内科,广东湛江524002

出　　处：《现代肿瘤医学》2006年第8期1009-1011,共3页Journal of Modern Oncology

摘　　要：目的:观察153钐一乙二胺四亚甲基膦酸(153Sm-EDTMP)联合宜利治(醋酸甲地孕酮分散片)改善晚期恶性肿瘤骨转移患者生活质量的疗效。方法:将87例晚期恶性肿瘤骨转移患者,随机分为治疗组及对照组,其中治疗组45例,用153Sm-EDTMP内照射联合宜利治治疗;对照组42例,单纯用153Sm-EDTMP内照射治疗。观察骨痛缓解效果、活动能力、Kanofsky评分及毒性反应。结果:治疗组在缓解骨痛总有效率方面与对照组差异无明显意义(P>0.05)。治疗组在活动能力、KPS评分改善的总有效率方面与对照组差异均有显著性意义(P<0.05)。2组的毒性反应主要是骨髓抑制,治疗组发生率较对照组略低,但差异无明显意义(P>0.05)。结论:153Sm-EDTMP联合宜利治能显著提高晚期恶性肿瘤骨转移患者的生活质量,不良反应小,值得临床推广使用。Objective：To observe the efficacy of ^153Sm-EDTMP combined with Yilizhi （megestrol acetate dispersible tablets） for improvement of QOL of patients with terminal osteoid metastasis. Methods ：87 patients with terminal osteoid metastasis were divided into two groups at random：45 patients in treatment group were treated with in- travenous injection of ^153Sm-EDTMP combined with Yilizhi ;42 patients in control group with intravenous injection of ^153 Sm- EDTMP alone. Relief of bone Pain, motor function, scores of Kamofsky performance scale （KPS） and toxicities were observed. Results： There was no significant difference in the total remission rate of pain in between （ P〉0.05）. Improvement of motor function and scores of KPS was more significant in treatment group（ P〈0.05）. Main toxicxy was myelosuppression in the two groups, Tonicities in treatment group were slightly lower than those in control group,though not significant（P〉0.05）. Condusion： ^153Sm- EDTMP combined with Yilizhi played a remarkable role in improving the QOL of patient with terminal osteoid metastasis with slight adverse reaction, with was good for clinical application.

关 键 词：骨转移 生活质量 ^153钐-乙二胺四亚甲基膦酸 醋酸甲地孕酮 

分 类 号：R730.58[医药卫生—肿瘤]