丙戊酸钠和碳酸锂治疗躁狂疗效和副作用的对照研究  

A case control study on the effects and side effects of Lithium and Valproate in treatment of the manic patients

作　　者：周宝林[1] 袁立新[1] 

机构地区：[1]北京市大兴区精神病院,北京102600

出　　处：《中国药物滥用防治杂志》2006年第3期145-146,149,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:比较碳酸锂和丙戊酸钠治疗躁狂患者的疗效和副作用。方法:将52例患者随机分配到丙戊酸钠治疗组和碳酸锂治疗组。于治疗前和治疗6周后应用Bech-Rafaelsen躁狂量表(Bech-RafaelsenManiaRatingScale,BRMS)评价两药物疗效,于治疗2、4、6周应用副反应量表(TreatmentEmergentSymptomScale,TESS)评价两药物的副作用。结果:丙戊酸钠组有效率为70.8%,碳酸锂组的有效率为68.2%,两组疗效相当(P>0.05)。而碳酸锂组的副反应发生较高。结论:丙戊酸钠治疗躁狂的疗效与碳酸锂相当,而副作用较小,故此优于碳酸锂。Objective： To investigate the therapeutic effects and side effects of Lithium and Valproate in treatment of the manic patients. Methods： Fifty-two patients with mania disorder were divided into two groups. One group was treated with Lithum, another one was treated with sodium Valproate. Bech-Rafaelsen Mania Rating Scale（BRMS） and Treatment Emergent Symptom Scale（TESS） were used to evaluate therapeutic effects and side effects. Results： There is no significant difference between the two groups in therapeutic effects （P 〉 0.05）. But the side effects in the patients treated with Lithum were much higher than the patients treated with valproate（P〈0.05）. Conclusion： Valproate is better than Lithum in treatment of the patients with mania disorder.

关 键 词：碳酸锂 丙戊酸钠 躁狂 

分 类 号：R749.4[医药卫生—神经病学与精神病学]