曲唑酮与呋喃唑酮治疗酒精滥用的对照研究  

A Controlled Study on Treatment of Alcohol Abuse with Trazodone and Furazolidone

作　　者：宋海东[1] 曹日芳[1] 陈树林[1] 汤剑平[1] 丁瑛[1] 沈鉴清[1] 陈梅芳[1] 

机构地区：[1]浙江省杭州市第七人民医院,杭州310013

出　　处：《中国药物滥用防治杂志》2006年第4期197-199,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:了解曲唑酮治疗酒精滥用的有效性并与呋喃唑酮进行比较。方法:采用随机对照的方法,用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和饮酒心理依赖评分表等,分别评定两组患者在处理前后的分值,然后作前后比较及组间比较。结果:两组患者治疗后比治疗前HAMD、HAMA及饮酒心理依赖评分均有显著差异(P<0.05或P<0.01),但两组间比较差异均无显著性。结论:曲唑酮对于戒除酒瘾有明显疗效,不失为一种新的选择。Objective： To investigate the effects of Trazodone in the treatment of alcohol abuse. Methods： 47 alcohol abuse patients were randomly selected as Trazodone-treatment group or Furazolidone-treatment group. The Hamilton depression scale （HAMD） and the Hamilton anxious scale （HAMA） were used to assess the effect and safety of the treatment. Results： For both groups of patients, the HAMD, HAMA scores at pre-treatment were significantly different compared with that of after treatment （P 〈 0.05 or P 〈 0.01）. There is no difference between the two treatment groups in the scores both before and after treatment. Conclusion： Trazodone can be used in treatment of patients with alcohol abuse.

关 键 词：曲唑酮 呋喃唑酮 酒精滥用 

分 类 号：R749.62[医药卫生—神经病学与精神病学]