我院1996-2005年抗肿瘤治疗用药分析  

Analysis of Antineoplastic Drugs Used in Cancer Center,Sun Yat-sen University, During the Period of 1996-2005

作　　者：钟锦堂[1] 黄红兵[1] 林子超[1] 刘韬[1] 林沛亮[1] 

机构地区：[1]华南肿瘤学国家重点实验室

出　　处：《癌症》2006年第8期1052-1058,共7页Chinese Journal of Cancer

摘　　要：背景与目的:近年来,癌症防治与研究进展迅速,抗肿瘤药物已经成为治疗癌症的主要手段之一,新的抗癌药物不断涌现。抗癌药物对于癌症的治疗和患者生存质量的提高发挥了巨大作用。中山大学肿瘤防治中心作为华南地区的肿瘤专科医院,抗肿瘤药物治疗在一定程度上可反映出这类药物应用变化特点,本研究旨在通过对我院近10年来抗肿瘤治疗药物的应用状况和发展趋势进行分析,为临床合理用药提供参考依据。方法:对1996至2005年各大类抗肿瘤药物的用药数据从消耗金额占当年全部用药金额的比例、各年度品种数量变化、国产和进口品种数量及消耗金额比例、主要抗肿瘤药使用频度以及临床应用等方面进行分析。结果:抗肿瘤药占药品年消耗总金额的31.0%～48.8%,10年来平均增长速度为21.5%,比全部用药金额的平均增长速度16.6%高出4.9个百分点;国产品种数一直比进口数多,消耗金额从只占进口品种的53.6%上升到2005年的116.3%;10年来销售金额增长最快的是植物类和杂类药物,烷化剂类最慢;紫杉类和铂类制剂销售额10年来均位居前列;一些新型的基因治疗药物和靶向治疗药物不断应用于临床。结论:抗肿瘤药物的研发与使用正朝着高效低毒、靶向、个体化的方向发展。BACKGROUND ＆ OBJECTIVE： Lately, the prevention, treatment and research of cancer have developed repidly. Antineoplastic drugs have become one of the major measures for cancer therapy. Many new antineoplastic drugs have been discovered and prepared, and used to treat tumors. Cancer Center of Sun Yat-sen University is one of the biggest cancer hospitals in South China. The use of antineoplastic drugs of this center can reflect changes in this area. This study was to analyze and evaluate the situation and trend of antineoplastic drugs used in Cancer Center, Sun Yatsen University from1996 and 2005, in order to provide references for the rational use of drugs in clinical application. METHODS. Consumption of antineoplastic drugs was analyzed by sum and defined daily dose （DDDs） ranking. RESULTS. The costs of antineoplastic drugs occupied 31.0%-48.8% of all drugs from 1996 to 2005; and the average increasing ratio is 21.5%. The cost rate of anti-cancer vegetable drugs and other genus increased the quickest, while the total costs of alkylate increased the slowest during the ten years. Some new monoantibodies and gene drugs were continuously applied in clinical use. CONCLUSION; The direction of the research and development of antineoplastic drugs is towards high efficiency, low toxicity and individualized use.

关 键 词：抗肿瘤药物 用药分析 趋势预测 

分 类 号：R730.5[医药卫生—肿瘤]