球后注射山莨菪碱对眼前部缺血性视神经病变血流动力学的影响  

The effect of retrobulbar injection with anisodamine on ocular blood velocity in anterior ischemic optic neuropathy

作　　者：朱晓青[1] 田蓓[1] 杨文利[1] 魏文斌[1] 翁乃清[1] 王兰[1] 

机构地区：[1]首都医科大学北京同仁眼科中心,100730

出　　处：《中华眼科杂志》2006年第7期606-610,共5页Chinese Journal of Ophthalmology

摘　　要：目的探讨眼前部缺血性视神经病变(anterior ischemic optic neuropathy,AION)患者球后注射扩血管药物的必要性。方法对39例(39只眼)临床诊断为AION患者,分别于球后注射山莨菪碱前、注射15 min和1 h后,应用彩色多普勒血流显像技术检测患眼各项血流动力学指标。包括眼动脉、视网膜中央动脉、鼻和颞侧睫状后短动脉收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)、单位时间内平均最大血流速度(TAMX)及血流搏动指数(PI)、阻力指数(RI)。同时将上述检测指标进行比较。结果AION患眼与健眼相比,睫状后短动脉各项参数指标差异有统计学意义(P<0．01)。山莨菪碱球后注射15 min和1 h后,各血流参数指标除阻力指数外,均较注射前增高,差异有统计学意义(P<0．01)。结论睫状后短动脉和视网膜中央动脉检测结果表明,球后注射山莨菪碱15 min和1 h后,CDFI显示血流动力学参数指标变化明显。山莨菪碱球后注射可以有效改善鼻、颞侧睫状后短动脉及视网膜中央动脉的血流速度。Objective To study the effect of retrobulbar injection with anisodamine on ocular blood velocity in anterior iscbemic optic neuropathy （AION）. Methods 15 minutes before injection, 15 minutes and 1 hour after injection, the blood flow velocity in 39 cases （39 eyes） diagnosed as AION was measured and analyzed by CDI, timed average maximum velocity, peak systohc velocity, end diastohc velocity, resistance index and pulsatility index of OA, CRA and PCA were recorded. Results Compared with the normal eyes, each parameter of SPCA was statistically significant. 15 minutes and 1 hour after post ocular injection of anisedamine, every parameter examined in the experiment was increased except resistance index compared with pre-injection （P 〈 0. 01 ） . Conclusions retrobulbar injection with anisedamine can effectively improve flow velocity of nasal and tempo short posterior ciliary artery and central retinal artery.

关 键 词：注射 病灶内 山莨菪碱 视神经疾病 超声检查 多普勒 彩色 血液动力学现象 

分 类 号：R774.6[医药卫生—眼科]