PI-3K/Akt/GSK-3p signaling cascades stimulated by insulin like growth factor-Ⅰcontribute to multiple myeloma cells proliferation and survival  

作　　者：WANG Meng-chang, FU Xue-de LI Man-xiang 

机构地区：[1]Department of Hematology, First Hospital of Xi＇an Jiaotong University, Xi＇an 710061, China [2]Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA

出　　处：《Chinese Medical Journal》2006年第14期1226-1229,共4页中华医学杂志（英文版）

摘　　要：Multiple myeloma is characterized by the accumulation of malignant plasma cells in thebone marrow. Significant progress in molecular mechanisms of signaling pathways underlying the survival and/or proliferation of these cells has been achieved. Interleukin 6 （IL-6） is an important cytokine leading to multiple myeloma （MM） cells growth and survival. However, some MM cells isolated from MM patients are poorly responsive to IL-6 stimulation or IL-6 independent. This phenomenon raises the possibility that other growth factors may also be involved in the development of MM. Insulin like growth factor-I （IGF-I） plays an important role in the proliferation of a variety of cell types, in the development and growth of multiple tumors and in the prevention of apoptosis. IGF-I has recently been reported to play such a role in stimulating the MM cells growth, it even induces MM cells proliferation in IL-6 dependent cells, yet the detailed signaling components triggered by IGF-I have not been completely clarified. Thus, the present study are to address the signaling cascades triggered by IGF-I in MM cells.Multiple myeloma is characterized by the accumulation of malignant plasma cells in thebone marrow. Significant progress in molecular mechanisms of signaling pathways underlying the survival and/or proliferation of these cells has been achieved. Interleukin 6 （IL-6） is an important cytokine leading to multiple myeloma （MM） cells growth and survival. However, some MM cells isolated from MM patients are poorly responsive to IL-6 stimulation or IL-6 independent. This phenomenon raises the possibility that other growth factors may also be involved in the development of MM. Insulin like growth factor-I （IGF-I） plays an important role in the proliferation of a variety of cell types, in the development and growth of multiple tumors and in the prevention of apoptosis. IGF-I has recently been reported to play such a role in stimulating the MM cells growth, it even induces MM cells proliferation in IL-6 dependent cells, yet the detailed signaling components triggered by IGF-I have not been completely clarified. Thus, the present study are to address the signaling cascades triggered by IGF-I in MM cells.

关 键 词：multiple myeloma insulin like growth factor-I PI-3K 

分 类 号：R733.3[医药卫生—肿瘤]