鼻咽癌放疗后程配合化疗临床研究  

Clinical study of irradiation combined with late course chemotherapy in nasopharyngeal carcinoma

作　　者：陈传本[1] 潘建基[1] 林少俊[1] 郑崴[1] 陈梅[1] 

机构地区：[1]福建医科大学教学医院福建省肿瘤医院放疗科,福建福州350014

出　　处：《中华肿瘤防治杂志》2006年第12期935-936,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为探讨鼻咽癌放疗后程配合化疗在治疗中晚期鼻咽癌中的价值,将1997年6月～2000年4月经病理确诊的首治鼻咽癌130例,随机分为放射治疗+后程化疗组(研究组)85例,和单纯放射治疗组(对照组)45例,分析对比两组的疗效。结果示,研究组1、3年局控率分别为97.6%(83/85)、89.4%(76/85),高于对照组的88.9%(40/45)、75.6%(34/45),两组间相比差异有统计学意义P<0.05,研究组1、3年生存率分别为98.8%(84/85)、70.6%(60/85),高于对照组的95.6%(43/45)、62.2%(28/45),但两组间相比差异无统计学意义P>0.05。两组急性毒副反应主要为白细胞下降、恶心呕吐及口咽部黏膜反应,研究组发生Ⅲ级以上口咽部黏膜反应的概率高于对照组,但两组差异无统计学意义P>0.05。初步研究结果提示,鼻咽癌放疗后程配合化疗对提高鼻咽癌治疗的局控率有潜在性的增益。其对远期生存率的影响将进一步随访。To study the value of irradiation combined with late course chemotherapy in advanced nasopharyngea carcinoma （NPC）, 130 primary cases with NPC, confirmed by pathology, were randomly divided into study group and control group from June 1997 to April 2000. Study group had 85 cases with irradiation combined with late course chemotherapy, and control group had 45 cases with irradiation alone. Then the results between the groups were analyzed. Local control rates of 1 and 3 years were 97.6% （83/85） and 89.4% （76/85） in study group, more than those in control group （88.9% （40/45） and 75.6% （34/45））, and there were significant difference （P^0.05）. Survival rates of 1 and 3 years were 98.8%（84/85） and 70. 6% （60/85） in study group, better than those in control group （95.6%（43/45） and 62.2%（28/45））, but there was no statistic difference （P〉0.05）. The main acute side effects included leukocytopenia, nausea, vomitting and mucitis of oral cavity in both groups. The incidence of over Ⅲ grade of mucitis in study group was more than that in control group, but there was no statistic difference （P〉0.05）. The preparatory result indicated that irradiation combined with late course chemotherapy in NPC may improve local control rate and it may have the ootential olus. Its influence on long-term survival needs further follow-up.

关 键 词：鼻咽肿瘤/放射治疗 鼻咽肿瘤/药物治疗 

分 类 号：R739.63[医药卫生—肿瘤]