周剂量艾素联合顺铂治疗老年晚期非小细胞肺癌近期疗效观察  

Observation with therapeutic effect on non-small cell lung cancer in the elderly patients with advanced stage using docetaxel weeklyand cisplatin low dose

作　　者：赵利红[1] 刘德生[1] 赵晶[1] 

机构地区：[1]徐州医学院附属医院肿瘤科,江苏徐州221002

出　　处：《中华肿瘤防治杂志》2006年第12期939-940,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为观察周剂量艾素(国产多西紫杉醇)联合顺铂治疗老年晚期非小细胞肺癌(NSCLC)的疗效和毒副反应。32例经细胞学或病理学证实的晚期非小细胞肺癌,采用周剂量艾素加低剂量顺铂联合化疗,每3周重复,WHO标准评估疗效和不良反应。32例患者均可进行疗效评价,其中CR1例,PR14例,SD13例,PD4例,总有效率48.4%。主要毒副反应为脱发明显、血液学毒性和轻微消化道反应。初步研究结果提示,国产多西紫杉醇周剂量联合低剂量顺铂化疗,对老年晚期非小细胞肺癌疗效明显,毒副反应轻,耐受性好。To observe the therapeutic effect on non small cell cancer （NSCLC）and untoward reactions in the elderly patients in advanced stage using docetaxel weekly and cisplatin low dose. Thirty-two elderly patients which have been proved to non small cell lung cancer（NSCLC）through cytology and pathology received docetaxel weekly and cisplatin low dose, followed by three week of rest,appraisaling untoward reactions with WHO standard. Among 32 pa- tints, completer esponse （CR） 1case, partial response （PR） 14cases, stable disease （SD） 13 caSeS, progressive disease （PD） 4cases, total response rate（RR）48.4%, The major untoward reactions are alopecie,hematologic toxicity and light alimentary canal reactive. Docetaxel weekly and cisplatin low dose used treating NSCLC in elderly patients has obviously effect and light untoward reactions. It will be worth to extent clinica luse.

关 键 词：肺肿瘤/药物疗法 药物疗法 联合 

分 类 号：R734.2[医药卫生—肿瘤]