复合离子盐对老年人细胞内Na^+、K^+、Ca^(2+)的影响及其机制  

Effects of Compound Ion Salt on Intra-erythrocyte Na^+, K^+, Ca^(2+) and Na^+-K^+-ATPase and Ca^(2+)-ATPase Activity in Old People

作　　者：刘军翔[1] 宋冬林[1] 石蕊[1] 张方宁[1] 朱勇[1] 李玉明[1] 

机构地区：[1]武警医学院附属医院心血管病研究所,天津300162

出　　处：《天津医药》2006年第7期439-441,共3页Tianjin Medical Journal

基　　金：天津市科委自然基金课题重大攻关项目(项目编号:023181411)

摘　　要：目的:观察复合离子盐对老年人细胞内Na+、K+、Ca2+及红细胞膜钠泵和钙泵活性的影响。方法:在天津市河东区社区中抽取226例老年人作为研究对象,其中高血压者112例,正常血压者114例。两者再随机分为离子盐组和普通加碘盐组,分别给予复合离子盐和普通加碘盐摄入,6个月后观察研究对象细胞内Na+、K+、Ca2+及钠泵、钙泵活性的变化。结果:6个月时高血压患者中离子盐组细胞内钠、钙离子浓度低于基线水平(P<0.05),但钾离子无明显变化。离子盐组钠泵、钙泵活性均明显高于基线水平(P<0.05),但在正常血压者中,2组与基线水平比较差异无统计学意义。结论:复合离子盐可增强钠泵、钙泵活性,使细胞内的钠、钙含量减少。Objective： To study the effect of compound ion salt on intra-erythrocyte Na^＋、K^＋、Ca^2＋ and Na^＋-K^＋-ATPase and Ca^2＋-ATPase activity in old people. Methods： A total 226 old people in the community were assigned to the hypertensive group （n = 112） and the normal group （n=114）. Each group was randomly assigned two groups respectively： the compound ion salt and the common iodine salt group. The activity of intra-erythrocyte Na^＋、K^＋、Ca^2＋ and Na^＋-K^＋-ATPase and Ca^2＋-ATPase was measured six months later. Results： The hypertension patients with the compound ion salt had lower level of intra-erythrocyte Na^＋ and Ca^2＋ than the base line（P 〈 0.05）, but there was no difference in intra-erythrocyte K^＋ six months later.The activity of Na^＋- K^＋-ATPase and Ca^2＋-ATPase was higher than base line in the compound ion group （P 〈 0.05）.The difference of two groups in the normal people had no statistical significance. Conclusion： Compound ion salt can increase the Na^＋K^＋-ATPase and Ca^2＋- ATPase activity result in reducing the amount of intra-erythrocyte Na^＋ and Ca^2＋.

关 键 词：盐类 膳食 低钠 Na^+K^+交换ATP酶 Ca^2+转运ATP酶 老年人 

分 类 号：R-332[医药卫生] R285.5