幽门螺旋杆菌细胞毒素与急性脑梗死的关系  

Correlation between Cytotoxin-Associated Gene-A-Bearing Strains of Helicobacter Pylori and Acute Cerebral Infarction

作　　者：邢永红[1] 赵欣春[1] 张本恕[2] 

机构地区：[1]天津市环湖医院,300060 [2]天津医科大学总医院

出　　处：《天津医药》2006年第7期466-467,共2页Tianjin Medical Journal

摘　　要：目的:探讨幽门螺旋杆菌细胞毒素(HP-CagA)与急性脑梗死的相关性。方法:100例新发脑梗死患者(脑梗死组)及50例健康对照者(对照组)均行HP-CagA-IgG抗体、中性粒细胞、C-反应蛋白(CRP)、血脂、血纤维蛋白原(Fbg)测定及经颅多普勒检查。结果:脑梗死组血清HP-CagA-IgG抗体阳性率(65%)高于对照组(38%),HP-CagA-IgG抗体阳性的脑梗死患者颈动脉粥样斑块、颈动脉狭窄阳性率及血CRP、血Fbg水平均高于HP-CagA-IgG抗体阴性的脑梗死患者。结论:HP-CagA感染与急性脑梗死的发生有关,可能为脑梗死的又一危险因素。Objective： To investigate the correlation between cytotoxin-associated gene-A-bearing strains of helicobacter pylori （HP-CagA） and acute cerebral infarction. Methods： 100 patients with new cerebral infarction and 50 healthy individuals （control） were enrolled in this trial.IgG antibody of HP-CagA, neutrophilic granulocyte, C-reactive protein, lipids and fibrinogen of blood were estimated by intracranial Doppler. Results： The positive rate of HP-CagA antibody of patients with cerebral infarction was 65% which was significantly higher than that of the control （ 38 %）, The positive rate of carotid stenosis, atheromatous plaque of carotid artery, C-reactive protein and fibrinogen of blood plasma in cerebral infarction patients with positive HP-CagA-IgG antibody were significantly higher than that in the negative. Conclusion： There is an association between HP-CagA infection and acute cerebral infarction, HP-CagA infection probably become another dangerous factor for acute cerebral infarction.

关 键 词：螺杆菌 幽门 螺杆菌 感染 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R573.1[医药卫生—临床医学]