白质体积减少所致多发性硬化症患者的脊髓萎缩  

Spinal cord atrophy in multiple sclerosis caused by white matter volume loss

作　　者：Gilmore C.P. DeLuca G.C. B L. 方伯言 

机构地区：[1]Department of Neurology, Medical School, Queen's Medical Centre NHS Trust, Nottingham, NG7 2UH, United Kingdom

出　　处：《世界核心医学期刊文摘（神经病学分册）》2006年第6期8-8,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Objective: To assess the relative contributions of white matter (WM) and gray matter (GM) volume loss to spinal cord atrophy in multiple sclerosis (MS). Design: Postmortem study of transverse sections obtained from 5 levels of the spinal cord, with measurement of the cross-sectional GM and WM areas. Setting: Department of Neuropathology, University of Nottingham, Nottingham, England. Patients: Fifty-five MS cases and 33 controls. Main Outcome Measures: Sizeof the WM and GM areas. Results: The WM area was significantly reduced in MS cases in the upper but not the lower cord levels. The GM area was not significantly different between MS and control cases. Conclusion: Spinal cord atrophy in MS is due to WM rather than GM volume loss.Objective： To assess the relative contributions of white matter （WM） and gray matter （GM） volume loss to spinal cord atrophy in multiple sclerosis （MS） . Design： Postmortem study of transverse sections obtained from 5 levels of the spinal cord, with measurement of the cross-sectional GM and WM areas. Setting： Department of Neuropathology, University of Nottingham, Nottingham, England. Patients： Fifty-five MS cases and 33 controls. Main Outcome Measures： Sizeof the WM and GM areas. Results： The WM area was significantly reduced in MS cases in the upper but not the lower cord levels. The GM area was not significantly different between MS and control cases. Conclusion： Spinal cord atrophy in MS is due to WM rather than GM volume loss.

关 键 词：多发性硬化症 脊髓萎缩 患者 体积 白质 脊髓节段 诺丁汉大学 尸检研究 观察指标 横断面 

分 类 号：R744.51[医药卫生—神经病学与精神病学] R651.2[医药卫生—临床医学]