嗜神经病毒与脑性瘫痪:人群病例对照研究  

Neurotropic viruses and cerebral palsy:Population based case-control study

作　　者：Gibson C.S. MacLennan A.H. Goldwater P.N. 张振 

机构地区：[1]University of Adelaide, Women's and Children's Hospital, Queen Victoria Building, 72 King William Road, Adelaide, SA 5006, Australia

出　　处：《世界核心医学期刊文摘（儿科学分册）》2006年第6期1-1,共1页

摘　　要：Objective: To investigate the association between cerebral palsy and direct evidence for perinatal exposure to neurotropic viruses. Design: Population based case-control study. Setting: Adelaide Women’s and Children’s Hospital Research Laboratory. Participants and main outcome measures: Newborn screening cards of 443 white case patients with cerebral palsy and 883 white controls were tested for viral nucleic acids from enteroviruses and herpes viruses by using polymerase chain reaction. Herpes group A viruses included herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus 8 (HHV-8); herpes group B viruses included varicella zoster virus (VZV) and human herpes viruses 6 and 7 (HHV-6 and HHV-7). Results: The prevalence of viral nucleic acids in the control population was high: 39.8%of controls tested positive, and the prevalence was highest in preterm babies. The detection of herpes group B viral nucleic acids increased the risk of developing cerebral palsy (odds ratio 1.68, 95%confidence interval 1.09 to 2.59). Conclusions: Perinatal exposure to neurotropic viruses is associated with preterm delivery and cerebral palsy.Objective： To investigate the association between cerebral palsy and direct evidence for perinatal exposure to neurotropic viruses. Design： Population based case-control study. Setting： Adelaide Women＇s and Children＇s Hospital Research Laboratory. Participants and main outcome measures： Newborn screening cards of 443 white case patients with cerebral palsy and 883 white controls were tested for viral nucleic acids from enteroviruses and herpes viruses by using polymerase chain reaction. Herpes group A viruses included herpes simplex viruses 1 and 2 （HSV- 1 and HSV-2）, Epstein-Barr virus （EBV）, cytomegalovirus （CMV）, and human herpes virus 8 （HHV- 8）; herpes group B viruses included varicella zoster virus （VZV） and human herpes viruses 6 and 7 （HHV-6 and HHV-7） . Results： The prevalence of viral nucleic acids in the control population was high： 39. 8% of controls tested positive, and the prevalence was highest in preterm babies. Thedetection of herpes group B viral nucleic acids increased the risk of developing cerebral palsy （odds ratio 1.68, 95% confidence interval 1.09 to 2. 59）. Conclusions：Perinatal exposure to neurotropic viruses is associated with preterm delivery and cerebral palsy.

关 键 词：病例对照研究 脑性瘫痪患儿 病毒感染 水痘-带状疱疹病毒(VZV) 神经 巨细胞病毒(CMV) EB病毒(EBV) 单纯疱疹病毒1型 疱疹病毒属 人疱疹病毒8型 

分 类 号：R735.2[医药卫生—肿瘤] R742.3[医药卫生—临床医学]