囊性纤维化新生儿的高血糖和胰岛素缺乏  

Hyperglycaemia and insulinopenia in a nenoate with cystic fibrosis

作　　者：Siahanidou T. Mandyla H. Doudounakis S. Anagnostakis D. 朱新菊 

机构地区：[1]First Department of Paediatrics, Athens University, Aghia Sophia Children's Hospital, Thivon and Levadias str, 11527, Athens, Greece

出　　处：《世界核心医学期刊文摘（儿科学分册）》2006年第6期10-11,共2页

摘　　要：Abnormal glucose tolerance is a frequent late complication of cystic fibrosis (CF), but the prevalence of CF-related diabetes mellitus (CFRD) in children less than 10 y old is less than 2%. The youngest child with CFRD reported to date was 6 mo of age. Insulinopenia is the primary cause of abnormal glucose toleranceCFRD, but it is unknown whether it may begin in the neonatal period. We describe a case of a neonate with CF who presented with hyperglycaemia in the diabetic range and marked insulinopenia. Insulinopenia and impaired glucose tolerance were permanent findings at 6 and 15 mo of age. Conclusion: This case suggests that abnormal glucose tolerancediabetes may occur much earlier in the course of CF, even during neonatal age. Careful follow-up and further studies in CF infants could reveal that the real incidence of glucose intolerance and diabetes in this age group has been underestimated.Abnormal glucose tolerance is a frequent late complication of cystic fibrosis （CF）, but the prevalence of CF-related diabetes meUitus （CFRD） in children less than 10 y old is less than 2%. The youngest child with CFRD reported to date was 6 mo of age. Insulinoponia is the primary cause of abnormal glucose tolerance/CFRD, but it is unknown whether it may begin in the neonatal period. We describe a case of a neonate with CF who presented with hyperglycaemia in the diabetic range and marked insulinoponia. Insulinopenia and impaired glucose tolerance were permanent findings at 6 and 15 mo of age. Conclusion： This case suggests that abnormal glucose tolerance/diabetes may occur much earlier in the course of CF, even during neonatal age. Careful follow-up and further studies in CF infants could reveal that the real incidence of glucose intolerance and diabetes in this age group has been underestimated.

关 键 词：胰岛素缺乏 囊性纤维化 新生儿期 葡萄糖耐量异常 高血糖 葡萄糖耐量降低 晚期并发症 葡萄糖耐受 糖尿病 6月龄 

分 类 号：R587.1[医药卫生—内分泌] R563[医药卫生—内科学]