斑马鱼胚胎发育中细胞凋亡的研究进展  

Research Progress on Cell Apoptosis during Embryonic Development of the Zebrafish (Danio rerio)

作　　者：王琳[1] 梁旭方[1] 廖婉琴[1] 周天鸿[1] 

机构地区：[1]暨南大学生命科学技术学院生物工程学系,广州510632

出　　处：《遗传》2006年第8期1009-1014,共6页Hereditas（Beijing)

基　　金：教育部留学回国人员启动基金项目~~

摘　　要：细胞凋亡是细胞在基因调控下发生的主动消亡过程,在脊椎动物胚胎发育过程中非常重要。斑马鱼作为一种十分理想的发育分子生物学研究模型,在有关细胞凋亡在诸如形态发生、性别分化等方面功能之活体在位研究中日益受到重视。目前,斑马鱼胚胎发育中主要凋亡通路研究已进行了不少工作,特别是caspase及其他凋亡调控基因在斑马鱼中已被成功克隆,通过转基因斑马鱼胚胎中胁迫诱导细胞凋亡并研究其信号通路以及斑马鱼胚胎形态发生的异常改变,为阐明这些凋亡调控基因与发育之间的关系提供了一个强有力的手段。Cells have a built-in death program through the regulation of genes. Apoptosis （programmed cell death） plays a very important role in the development of the vertebrate embryo. The zebrafish （Danio rerio） has become a useful and ideal model in molecular developmental biology for in vivo study on the function of apoptosis in morphogenesis, sex differentiation and so on, and has already been garnering more and more attention. At present, much progress has been made regarding apoptotic pathways in zebrafish development. Caspases and other regulatory apoptotic genes have been cloned successfully. Moreover, transgenic zebrafish embryos have been induced to undergo apoptosis in vivo to study apoptotic signaling pathways and the abnormal morphological changes during embryogenesis. Transgenic zebrafish has provided a powerful tool for illuminating the interaction between regulatory apoptotic genes and vertebrate development.

关 键 词：斑马鱼 胚胎发育 细胞凋亡 信号通路 

分 类 号：Q954.4[生物学—动物学] Q953