急性呼吸窘迫综合征早期兔红细胞流变学特性的改变  

The Change of Rheological Properties of Rabbit Red Blood Cells during the Development of Acute Respiratory Distress Syndrome

作　　者：陈希[1] 邢俊杰[2] 贺东奇[3] 文宗曜[1] 

机构地区：[1]北京大学医学部生物物理系,北京100083 [2]北京大学第三医院,北京100083 [3]北京大学医学部生物数学教研室,北京100083

出　　处：《中国血液流变学杂志》2006年第2期157-160,共4页Chinese Journal of Hemorheology

基　　金：国家自然科学基金资助项目(100572005)

摘　　要：目的探讨油酸型急性呼吸窘迫综合征(ARDS)早期红细胞流变学特性的改变及其机制。方法经颈静脉注射油酸复制兔ARDS模型,颈动脉插管心室采血测定血液流变性,红细胞电泳率、渗透脆性、膜流动性变化,观察红细胞丙二醛 (MDA)含量和超氧化物歧化酶(SOD)活性的变化。结果 ARDS早期红细胞渗透脆性增加、红细胞变形指数、取向指数、小变形指数降低,红细胞电泳率和红细胞膜流动性降低,测定红细胞MDA增高,而SOD降低。结论ARDS兔早期出现红细胞流变学特性的改变,ARDS时氧化应激可促使红细胞流变学的改变。Objective To investigate the change of reheological properties of rabbit red blood cell during the development of acute lung injury. Method Rheological properties of rabbit red blood cells were measured by ektacytometry,the biophysical changes in the membrane of rabbits red blood cells （RBC） were measured by the fluorescence depolarization method. Results The results show that the membrane fluidity of red cells decreased greatly during the early stage of acute lung injury,the change of rheological properties appear early. Conclusion This suggests the rheological properties may be useful for investigating mechanisms of acute lung injury and evaluating the effects of therapy on acute lung injury.

关 键 词：急性呼吸窘迫综合征 丙二醛 超氧化物歧化酶 血液流变学 红细胞膜流动性 

分 类 号：R730.5[医药卫生—肿瘤]