食管鳞癌组织中胸苷磷酸化酶检测  

Expression of thymidine phosphorylase in esophageal carcinoma tissue

作　　者：尚育红[1] 王进[2] 李继昌[2] 

机构地区：[1]郑州大学第一附属医院肿瘤科,郑州450052 [2]郑州大学第一附属医院消化内科,郑州450052

出　　处：《郑州大学学报（医学版）》2006年第4期744-746,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨食管鳞癌组织中胸苷磷酸化酶(TP)的表达与各临床病理因素之间的关系。方法:采用免疫组织化学SP法检测经病理证实的48例食管鳞癌组织、24例不典型增生组织和24例癌旁正常食管黏膜组织TP的表达。结果:①食管鳞癌组织中TP阳性表达率(81.25%(39/48))明显高于正常食管黏膜组织(8.33%(2/24))和不典型增生组织(41.67%(10/24,P<0.01))。②TP表达与食管癌患者的年龄、性别、肿瘤发生部位、分化程度、浸润深度均无关(P>0.05);但与肿瘤淋巴结转移明显相关(P<0.05)。结论:TP与食管癌的发生发展及淋巴结转移有关,抑制TP的表达能抑制肿瘤的血管形成,阻断食管癌的发生发展,为抗血管生成治疗提供帮助。Aim： To assess the correlations between the expressions of thymidine phosphorylase （TP） and clinicopathological factors in esophageal carcinoma tissue. Mothods：The expressions of TP in 48 cases of esophageal carcinoma tissue, 24 cases of tumor borderline tissue and 24 cases of normal esophageal tissue were examined using S-P immunohistochemistry. Results： In esophageal carcinoma tissue, the positive expression rate of TP （81.25% （39/48）） was significantly higher than that in normal gastric tissue （8.33% （2/24）） and tumor borderline tissue （41.67% （ 10/24 ,P 〈0.01 ） ）. There were no correlations between the expression of TP and the age, gender of patients, the site of tumor, the extent of differentiation or the depth of invasion. The expression of TP was only correlated with lymph node metastasis （ P 〈 0.05 ）. Conclusion ： The expression of TP is correlated with development and lymph node metastasis of esophageal carcinoma. To restrain the expression of TP could prevent tumor angiogenesis and development of esophageal carcinoma, and provide new ways for antiangiogenie therapy of esophageal carcinoma.

关 键 词：胸苷磷酸化酶 食管肿瘤 癌 

分 类 号：R735.1[医药卫生—肿瘤]