喉鳞癌组织中Survivin蛋白与核因子-κB的表达  

Expression of Survivin and nuclear factor κappaB in laryngeal squamous cell carcinoma tissue

作　　者：郭宝凤[1] 董明敏[1] 郭漳生[2] 

机构地区：[1]郑州大学第一附属医院耳鼻咽喉科 [2]郑州大学基础医学院人体解剖学教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2006年第4期746-749,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨Survivin与核因子κB(NFκB)p65蛋白对喉鳞癌发生发展的影响。方法:用免疫组化技术检测20例喉正常黏膜(LNM)、38例喉不典型增生(LAH)和50例喉鳞癌(LSCC)组织中Survivin及NFκBp65的表达情况。结果:①LNM、LAH和LSCC组织中Survivin阳性表达率分别为0.0%(0/20)、36.8%(14/38)和72.0%(36/50),差异有统计学意义(P<0.01);NFκBp65阳性表达率分别为0.0%(0/20)、23.7%(9/38)和64.0%(32/50),差异亦有统计学意义(P<0.01)。②Survivin的表达与LSCC的淋巴结转移及T分期有关(P<0.05),NFκBp65的表达与LSCC的淋巴结转移有关(P<0.01)。③LSCC组织中,Survivin和NFκBp65的表达呈正相关(rs=0.367,P=0.009)。结论:LSCC组织中Survivin与NFκB均异常活化,2者可能共同参与了LSCC的发生和发展。Aim： To explore the effect of Survivin and NF-κBp65 on the occurrence and progress of laryngeal squamous cell carcinoma（LSCC）. Methods ：The expression of Survivin and NF-κBp65 in 20 cases of laryngeal normal mucosa （LNM） , 38 cases of laryngeal atypical hyperplasia（LAH） and 50 cases of LSCC were detected using immunohistoehemieal method. Results： In LNM, LAH and LSCC, the positive rates of Survivin protein were 0. 0% （0/20） ,36.8% （14/38）and 72.0% （36/50）, respectively, and the differences between them were statistically significant （P 〈 0.01 ）;those of NF- κBp65 protein were 0. 0% （ 0/20 ） , 23.7% （ 9/38 ） and 64.0% （ 32/50 ） , respectively, and the differences between them were also statistically significant（ P 〈 0.01 ）. Survivin positive rates were correlated with lymph node metastasis and T stage, while the expression of NF-κBp65 was correlated with lymph node metastasis in LSCC. A positive relation was found between Survivin and NF-κBp65 expression in LSCC （ rs = 0. 367 ,P = 0. 009 ）. Conclusion ： Survivin and NF-κB are both abnormally activated and are involved in the occurrence and progress of LSCC.

关 键 词：喉肿瘤 鳞状细胞癌 SURVIVIN基因 核因子-ΚB 

分 类 号：R739.65[医药卫生—肿瘤]