上颌窦鳞癌细胞雌激素、孕激素受体的研究  

Study on Estrogen and Progesterone Receptors in Maxillary Sinus Squamous Cell Carcinoma

作　　者：许平[1] 陈东[1] 楚非 冯丽云[1] 高延昭[1] 许伟 

机构地区：[1]河南医科大学病理教研室,周口纺织医院耳鼻咽喉科,北京中医药大学,河南医科大学卫生统计学教研室

出　　处：《河南肿瘤学杂志》1996年第5期324-326,共3页Henan Journal of Oncology

摘　　要：应用免疫组化ＡＢＣ法对５３例上颌窦鳞癌组织及２１例非癌组织（包括９例正常上颌窦组织、１２例上颌窦乳头状瘤组织）雌激素受体（ＥＲ）和孕激素受体（ＰＲ）的表达进行了检测。结果表明：上颌窦鳞癌的ＥＲ阳性率为４１．５１％，ＰＲ阳性率为３７．７４％；而非癌组织的ＥＲ、ＰＲ阳性率为９．５２％，差异有显著性（Ｐ＜０．０５）。表明部分上颌窦鳞癌组织中存在ＥＲ、ＰＲ、ＥＲ、ＰＲ表达密切相关（Ｐ＜０．００１）。上颌窦鳞癌细胞中ＥＲ、ＰＲ阳性率与组织学分级成反比，且在染色程度上有明显的差别。ＥＲ和ＰＲ的表达与年龄、性别无关（Ｐ＞０．０５）。本文有可能为上颌窦鳞癌患者的内分泌治疗提供参考。Using ABC immunohistochemistry method,we examined the expression of estrogen andprogesterone receptors in 53 cases of maxillary sinus squamous cell carcinoma (MSSCC) andin 21 cases of noncarcioma tissues (9 cases of normal maxillary sinus mucosa, 12 cases of papilloma) The results showed that the positive rates of ER and PR were 41. 51% and 37.74% respectively in MSSCC and were 9.52% and 9. 52% in noncarcinoma tissues,the difference was significant (P<0. 05). This indicated that ER and PR really existed in maxillary sinus neoplasms and there was much closer relationship between ER and PR(P<0. 05). Therewas an inverse relation between the positive rates and the histolagical grades of ER and PR incancer cells and staining intensity was apparently different. The expression of PR and ERhad no relation with the patient's sex and age (P>0. 05). This paper may provide referencefor endocrine therapy of MSSCC.

关 键 词：上颌窦鳞癌 雌激素受体 孕激素受体 免疫组织化学 

分 类 号：R739.6[医药卫生—肿瘤]