脑血栓形成急性期后患者血浆t－PA、PAI活性动态变化  

Dynamic changes of plasma t PA,PAI activity in patients with cerebral thrombosis.

作　　者：沈志祥[1,2,3] 周士枋[1,2,3] 励建安 高润[1,2,3] 

机构地区：[1]江苏省淮阴市第二人民医院康复医学科 [2]江苏省人民医院康复医学科 [3]南京医科大学脑科医院康复医学科

出　　处：《临床神经病学杂志》1996年第5期262-263,共2页Journal of Clinical Neurology

摘　　要：动态观察２０例脑血栓形成患者急性期后及随后３周的血浆ｔ－ＰＡ、ＰＡＩ活性水平，并与正常老年人对照，以了解脑血栓形成后患者纤溶活性的变化规律，并探讨其临床意义。结果发现脑血栓形成患者血浆ｔ－ＰＡ活性低于正常老年人（Ｐ＜０．００１），随后３周，ＰＡＩ活性升高（Ｐ＝０．０５９），ＰＡＩ／ｔ－ＰＡ值升高（Ｐ＜０．０５）。We observed 20 cases of cerebral thrombosis plasma t PA and PAI activity in subacute and behine three weeks were determined respectively.Comparing these data to normal elderlys one,so as to found out rule of fibrinolytic activity and inquired into clinical significance in cerebral thrombosis.The results showed that t PA activity was lower in cerebral thrombosis than in normal elderly ( P <0.001).PAI activity increased ( P =0.059) and PAI/t PA ratio increased ( P <0.05) after three weeks.Fibrinolytic activity trended to decrease.

关 键 词：脑血栓形成 组织型 纤溶酶原激活物 病理 

分 类 号：R743.320.2[医药卫生—神经病学与精神病学]